Using QTL to Identify Genes and Pathways Underlying the Regulation and Production of Milk Components in Cattle
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Date
2023-03-02
Open Access Location
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI (Basel, Switzerland)
Rights
(c) 2023 The Author/s
CC BY 4.0
CC BY 4.0
Abstract
Milk is a complex liquid, and the concentrations of many of its components are under genetic control. Many genes and pathways are known to regulate milk composition, and the purpose of this review is to highlight how the discoveries of quantitative trait loci (QTL) for milk phenotypes can elucidate these pathways. The main body of this review focuses primarily on QTL discovered in cattle (Bos taurus) as a model species for the biology of lactation, and there are occasional references to sheep genetics. The following section describes a range of techniques that can be used to help identify the causative genes underlying QTL when the underlying mechanism involves the regulation of gene expression. As genotype and phenotype databases continue to grow and diversify, new QTL will continue to be discovered, and although proving the causality of underlying genes and variants remains difficult, these new data sets will further enhance our understanding of the biology of lactation.
Description
Keywords
lactation, lactogenesis, mammary biology, mammogenesis, quantitative trait loci
Citation
Lopdell TJ. (2023). Using QTL to Identify Genes and Pathways Underlying the Regulation and Production of Milk Components in Cattle.. Animals (Basel). 13. 5. (pp. 911-).