The relationship between hair metabolites, air pollution exposure and gestational diabetes mellitus: A longitudinal study from pre-conception to third trimester.

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dc.citation.volume13
dc.contributor.authorChen X
dc.contributor.authorZhao X
dc.contributor.authorJones MB
dc.contributor.authorHarper A
dc.contributor.authorde Seymour JV
dc.contributor.authorYang Y
dc.contributor.authorXia Y
dc.contributor.authorZhang T
dc.contributor.authorQi H
dc.contributor.authorGulliver J
dc.contributor.authorCannon RD
dc.contributor.authorSaffery R
dc.contributor.authorZhang H
dc.contributor.authorHan T-L
dc.contributor.authorBaker PN
dc.contributor.editorZhou N
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-10-30T22:39:44Z
dc.date.available2024-10-30T22:39:44Z
dc.date.issued2022-12-02
dc.description.abstractBACKGROUND: Gestational diabetes mellitus (GDM) is a metabolic condition defined as glucose intolerance with first presentation during pregnancy. Many studies suggest that environmental exposures, including air pollution, contribute to the pathogenesis of GDM. Although hair metabolite profiles have been shown to reflect pollution exposure, few studies have examined the link between environmental exposures, the maternal hair metabolome and GDM. The aim of this study was to investigate the longitudinal relationship (from pre-conception through to the third trimester) between air pollution exposure, the hair metabolome and GDM in a Chinese cohort. METHODS: A total of 1020 women enrolled in the Complex Lipids in Mothers and Babies (CLIMB) birth cohort were included in our study. Metabolites from maternal hair segments collected pre-conception, and in the first, second, and third trimesters were analysed using gas chromatography-mass spectrometry (GC-MS). Maternal exposure to air pollution was estimated by two methods, namely proximal and land use regression (LUR) models, using air quality data from the air quality monitoring station nearest to the participant's home. Logistic regression and mixed models were applied to investigate associations between the air pollution exposure data and the GDM associated metabolites. RESULTS: Of the 276 hair metabolites identified, the concentrations of fourteen were significantly different between GDM cases and non-GDM controls, including some amino acids and their derivatives, fatty acids, organic acids, and exogenous compounds. Three of the metabolites found in significantly lower concentrations in the hair of women with GDM (2-hydroxybutyric acid, citramalic acid, and myristic acid) were also negatively associated with daily average concentrations of PM2.5, PM10, SO2, NO2, CO and the exposure estimates of PM2.5 and NO2, and positively associated with O3. CONCLUSIONS: This study demonstrated that the maternal hair metabolome reflects the longitudinal metabolic changes that occur in response to environmental exposures and the development of GDM.
dc.description.confidentialfalse
dc.format.pagination1060309-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/36531491
dc.identifier.citationChen X, Zhao X, Jones MB, Harper A, de Seymour JV, Yang Y, Xia Y, Zhang T, Qi H, Gulliver J, Cannon RD, Saffery R, Zhang H, Han T-L, Baker PN. (2022). The relationship between hair metabolites, air pollution exposure and gestational diabetes mellitus: A longitudinal study from pre-conception to third trimester.. Front Endocrinol (Lausanne). 13. (pp. 1060309-).
dc.identifier.doi10.3389/fendo.2022.1060309
dc.identifier.eissn1664-2392
dc.identifier.elements-typejournal-article
dc.identifier.issn1664-2392
dc.identifier.number1060309
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71880
dc.languageeng
dc.publisherFrontiers Media S.A.
dc.publisher.urihttps://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.1060309/full
dc.relation.isPartOfFront Endocrinol (Lausanne)
dc.rights(c) 2022 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectair pollution
dc.subjectcohort study
dc.subjectgestational diabetes mellitus
dc.subjecthair analysis
dc.subjectmetabolomics
dc.subjectPregnancy
dc.subjectInfant
dc.subjectHumans
dc.subjectFemale
dc.subjectDiabetes, Gestational
dc.subjectPregnancy Trimester, Third
dc.subjectParticulate Matter
dc.subjectAir Pollutants
dc.subjectLongitudinal Studies
dc.subjectAir Pollution
dc.subjectHair
dc.titleThe relationship between hair metabolites, air pollution exposure and gestational diabetes mellitus: A longitudinal study from pre-conception to third trimester.
dc.typeJournal article
pubs.elements-id458680
pubs.organisational-groupCollege of Health
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