Metabolite profiling of peripheral blood plasma in pigs in early postnatal life fed whole bovine, caprine or ovine milk

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dc.citation.volume10
dc.contributor.authorJena A
dc.contributor.authorMontoya CA
dc.contributor.authorFraser K
dc.contributor.authorGiezenaar C
dc.contributor.authorYoung W
dc.contributor.authorMullaney JA
dc.contributor.authorDilger RN
dc.contributor.authorRoy D
dc.contributor.authorMcNabb WC
dc.contributor.authorRoy NC
dc.contributor.editorLeroux C
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-07-12T01:52:16Z
dc.date.available2024-07-12T01:52:16Z
dc.date.issued2023-09-26
dc.description.abstractRuminants' milk is commonly used for supplying nutrients to infants when breast milk is unavailable or limited. Previous studies have highlighted the differences between ruminants' milk composition, digestion, absorption, and fermentation. However, whether consuming different ruminants' milk impact the appearance of the circulatory blood metabolites in the early postnatal life is not well understood. The analysis conducted here aimed to determine the effect of feeding exclusively whole milk from bovine, caprine or ovine species to pigs, approximately 7 days-old for 15 days, on circulatory blood plasma metabolites. Relative intensities of plasma metabolites were detected using a liquid chromatography-mass spectrometry based metabolomic approach. Seven polar and 83 non-polar (lipids) metabolites in plasma were significantly different (false discovery rate < 0.05) between milk treatments. These included polar metabolites involved in amino acid metabolism and lipids belonging to phosphatidylcholine, lysophosphatidylcholine, sphingomyelin, and triglycerides. Compared to the caprine or bovine milk group, the relative intensities of polar metabolites and unsaturated triglycerides were higher in the peripheral circulation of the ovine milk group. In contrast, relative intensities of saturated triglycerides and phosphatidylcholine were higher in the bovine milk group compared to the ovine or caprine milk group. In addition, correlations were identified between amino acid and lipid intake and their appearance in peripheral blood circulation. The results highlighted that consuming different ruminants' milk influences the plasma appearance of metabolites, especially lipids, that may contribute to early postnatal life development in pigs.
dc.description.confidentialfalse
dc.format.pagination1242301-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37823089
dc.identifier.citationJena A, Montoya CA, Fraser K, Giezenaar C, Young W, Mullaney JA, Dilger RN, Roy D, McNabb WC, Roy NC. (2023). Metabolite profiling of peripheral blood plasma in pigs in early postnatal life fed whole bovine, caprine or ovine milk.. Front Nutr. 10. (pp. 1242301-).
dc.identifier.doi10.3389/fnut.2023.1242301
dc.identifier.eissn2296-861X
dc.identifier.elements-typejournal-article
dc.identifier.issn2296-861X
dc.identifier.number1242301
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70164
dc.languageeng
dc.publisherFrontiers Media S.A.
dc.publisher.urihttps://www.frontiersin.org/articles/10.3389/fnut.2023.1242301/full
dc.relation.isPartOfFront Nutr
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectearly life
dc.subjectinfant
dc.subjectlipids
dc.subjectmetabolomics
dc.subjectnutrition
dc.subjectpigs
dc.subjectplasma
dc.subjectruminant milk
dc.titleMetabolite profiling of peripheral blood plasma in pigs in early postnatal life fed whole bovine, caprine or ovine milk
dc.typeJournal article
pubs.elements-id481006
pubs.organisational-groupOther
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