Enhanced airway sensory nerve reactivity in non-eosinophilic asthma
dc.citation.issue | 1 | |
dc.citation.volume | 8 | |
dc.contributor.author | Ali H | |
dc.contributor.author | Brooks C | |
dc.contributor.author | Crane J | |
dc.contributor.author | Beasley R | |
dc.contributor.author | Holgate S | |
dc.contributor.author | Gibson P | |
dc.contributor.author | Pattemore P | |
dc.contributor.author | Tzeng Y-C | |
dc.contributor.author | Stanley T | |
dc.contributor.author | Pearce N | |
dc.contributor.author | Douwes J | |
dc.date.accessioned | 2023-06-21T21:41:40Z | |
dc.date.available | 2021-11 | |
dc.date.available | 2021-10-19 | |
dc.date.available | 2023-06-21T21:41:40Z | |
dc.date.issued | 2/11/2021 | |
dc.description | © Author(s) (or their employer(s)) 2021. | |
dc.description.abstract | BACKGROUND: Neural mechanisms may play an important role in non-eosinophilic asthma (NEA). This study compared airway sensory nerve reactivity, using capsaicin challenge, in eosinophilic asthma (EA) and NEA and non-asthmatics. METHODS: Thirty-eight asthmatics and 19 non-asthmatics (aged 14-21 years) underwent combined hypertonic saline challenge/sputum induction, fractional exhaled nitric oxide, atopy and spirometry tests, followed by capsaicin challenge. EA and NEA were defined using a sputum eosinophil cut-point of 2.5%. Airway hyperreactivity was defined as a ≥15% drop in FEV1 during saline challenge. Sensory nerve reactivity was defined as the lowest capsaicin concentration that evoked 5 (C5) coughs. RESULTS: Non-eosinophilic asthmatics (n=20) had heightened capsaicin sensitivity (lower C5) compared with non-asthmatics (n=19) (geometric mean C5: 58.3 µM, 95% CI 24.1 to 141.5 vs 193.6 µM, 82.2 to 456.0; p<0.05). NEA tended to also have greater capsaicin sensitivity than EA, with the difference in capsaicin sensitivity between NEA and EA being of similar magnitude (58.3 µM, 24.1 to 141.5 vs 191.0 µM, 70.9 to 514.0) to that observed between NEA and non-asthmatics; however, this did not reach statistical significance (p=0.07). FEV1 was significantly reduced from baseline following capsaicin inhalation in both asthmatics and non-asthmatics but no differences were found between subgroups. No associations with capsaicin sensitivity and atopy, sputum eosinophils, blood eosinophils, asthma control or treatment were observed. CONCLUSION: NEA, but not EA, showed enhanced capsaicin sensitivity compared with non-asthmatics. Sensory nerve reactivity may therefore play an important role in the pathophysiology of NEA. | |
dc.description.publication-status | Published | |
dc.identifier | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000715379200004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef | |
dc.identifier | ARTN e000974 | |
dc.identifier.citation | BMJ OPEN RESPIRATORY RESEARCH, 2021, 8 (1) | |
dc.identifier.doi | 10.1136/bmjresp-2021-000974 | |
dc.identifier.eissn | 2052-4439 | |
dc.identifier.elements-id | 449365 | |
dc.identifier.harvested | Massey_Dark | |
dc.identifier.uri | https://hdl.handle.net/10179/18328 | |
dc.publisher | BMJ Publishing Group Ltd and the British Thoracic Society | |
dc.relation.isPartOf | BMJ OPEN RESPIRATORY RESEARCH | |
dc.subject | asthma | |
dc.subject | asthma mechanisms | |
dc.subject | asthma epidemiology | |
dc.subject | paediatric asthma | |
dc.title | Enhanced airway sensory nerve reactivity in non-eosinophilic asthma | |
dc.type | Journal article | |
pubs.notes | Not known | |
pubs.organisational-group | /Massey University | |
pubs.organisational-group | /Massey University/College of Health | |
pubs.organisational-group | /Massey University/College of Health/Research Centre for Hauora and Health |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- Enhanced airway sensory nerve reactivity in non-eosinophilic asthma.pdf
- Size:
- 464.84 KB
- Format:
- Adobe Portable Document Format
- Description: