Disseminated Rasamsonia argillacea infection in a dog.

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dc.citation.issue5
dc.citation.volume71
dc.contributor.authorPolak S
dc.contributor.authorKaralus W
dc.contributor.authorWorth AJ
dc.contributor.authorCave NJ
dc.coverage.spatialEngland
dc.date.accessioned2024-07-24T00:48:20Z
dc.date.available2024-07-24T00:48:20Z
dc.date.issued2023-06-19
dc.description.abstractCASE HISTORY: A 4-year-old, male neutered Borzoi presented for unlocalised pain and frequent episodes of vocalisation. CLINICAL FINDINGS: Pain was localised to the lumbar spine and radiographs revealed a L3-L4 lesion consistent with discospondylitis. The dog was treated for presumptive bacterial discospondylitis with surgical debridement, spinal stabilisation, and cephalexin. Samples collected from the affected intervertebral disc at the time of surgery revealed lymphoplasmacytic inflammation with no causative agent identified on histopathology or bacterial culture. After an initial period of improvement, signs recurred despite an 8-week antibiotic course, with the development of inappetence, weight loss, polydipsia, and polyuria. Repeat radiographs revealed a new cervical intervertebral lesion, and concurrent pyelonephritis was diagnosed based on blood and urine results. Fungal culture of urine resulted in growth of Rasamsonia argillacea species complex and disseminated fungal disease was clinically diagnosed. Antifungal treatment was commenced, however the dog deteriorated, and euthanasia was performed. PATHOLOGICAL FINDINGS: Multifocal white plaques were grossly visualised in the spleen, mesenteric lymph nodes, cervical vertebrae, and kidneys. Periodic acid-Schiff-positive, fine, parallel-walled, occasionally branching, septate hyphae 5-10 μm in diameter, and conidia 5-7 μm in diameter were found on sectioning all organs. R. argillacea species complex was identified by fungal culture of urine and was considered the species of fungal organism seen histologically. The isolate was subsequently confirmed as R. argillacea by DNA sequencing. DIAGNOSIS: Disseminated Rasamsonia argillacea infection. CLINICAL RELEVANCE: Rasamsonia argillacea species complex is a recognised invasive mycosis in veterinary medicine, with disseminated disease causing significant clinical complications and death. This is believed to be the first report of infection caused by R. argillacea in a dog in Australasia and highlights the importance of awareness of a potential fungal aetiology in dogs with discospondylitis. Abbreviations: CLSI: Clinical and Laboratory Standards Institute; CRI: Constant rate infusion; MEC: Minimum effective concentration; MIC: Minimum inhibitory concentration; PAS: Periodic acid-Schiff.
dc.description.confidentialfalse
dc.edition.edition2023
dc.format.pagination267-274
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37173868
dc.identifier.citationPolak S, Karalus W, Worth AJ, Cave NJ. (2023). Disseminated Rasamsonia argillacea infection in a dog.. N Z Vet J. 71. 5. (pp. 267-274).
dc.identifier.doi10.1080/00480169.2023.2214511
dc.identifier.eissn1176-0710
dc.identifier.elements-typejournal-article
dc.identifier.issn0048-0169
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70299
dc.languageeng
dc.publisherTaylor and Francis Group
dc.publisher.urihttps://www.tandfonline.com/doi/full/10.1080/00480169.2023.2214511
dc.relation.isPartOfN Z Vet J
dc.rights(c) 2023 The Author/s
dc.rightsCC BY-NC-ND 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectRasamsonia argillacea
dc.subjectdiscospondylitis
dc.subjectdisseminated
dc.subjectfungus
dc.subjectmycosis
dc.subjectDogs
dc.subjectMale
dc.subjectAnimals
dc.subjectPeriodic Acid
dc.subjectAntifungal Agents
dc.subjectMycoses
dc.subjectEurotiales
dc.subjectDog Diseases
dc.titleDisseminated Rasamsonia argillacea infection in a dog.
dc.typeJournal article
pubs.elements-id461672
pubs.organisational-groupOther
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