Panic or peace - prioritising infant welfare when medicating feverish infants: a grounded theory study of adherence in a paediatric clinical trial

Simple item page
dc.citation.issue1
dc.citation.volume22
dc.contributor.authorTan E
dc.contributor.authorHoare K
dc.contributor.authorRiley J
dc.contributor.authorFernando K
dc.contributor.authorHaskell L
dc.contributor.authorMcKinlay CJD
dc.contributor.authorDalziel SR
dc.contributor.authorBraithwaite I
dc.coverage.spatialEngland
dc.date.accessioned2023-08-15T21:13:11Z
dc.date.accessioned2023-09-04T01:41:19Z
dc.date.available2022-04-11
dc.date.available2023-08-15T21:13:11Z
dc.date.available2023-09-04T01:41:19Z
dc.date.issued2022-04-11
dc.date.updated2023-08-14T23:46:39Z
dc.descriptionOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
dc.description.abstractBackground Literature on factors influencing medication adherence within paediatric clinical trials is sparse. The Paracetamol and Ibuprofen in the Primary Prevention of Asthma in Tamariki (PIPPA Tamariki) trial is an open-label, randomised controlled trial aiming to determine whether paracetamol treatment, compared with ibuprofen treatment, as required for fever and pain in the first year of life, increases the risk of asthma at age six years. To inform strategies for reducing trial medication crossovers, understanding factors influencing the observed ibuprofen-to-paracetamol crossovers (non-protocol adherence) is vital. The aim of this study was to investigate the factors influencing the decision-making process when administering or prescribing ibuprofen to infants that may contribute to the crossover events in the PIPPA Tamariki trial. Methods Constructivist grounded theory methods were employed. We conducted semi-structured interviews of caregivers of enrolled PIPPA Tamariki infants and healthcare professionals in various healthcare settings. Increasing theoretical sensitivity of the interviewers led to theoretical sampling of participants who could expand on the teams’ early constructed codes. Transcribed interviews were coded and analysed using the constant comparative method of concurrent data collection and analysis. Results Between September and December 2020, 20 participants (12 caregivers; 8 healthcare professionals) were interviewed. We constructed a grounded theory of prioritising infant welfare that represents a basic social process when caregivers and healthcare professionals medicate feverish infants. This process comprises three categories: historical, trusting relationships and being discerning; and is modified by one condition: being conflicted. Participants bring with them historical ideas. Trusting relationships with researchers, treating clinicians and family play a central role in enabling participants to challenge historical ideas and be discerning. Trial medication crossovers occur when participants become conflicted, and they revert to historical practices that feel familiar and safer. Conclusions We identified factors and a basic social process influencing ibuprofen use in infants and trial medication crossover events, which can inform strategies for promoting adherence in the PIPPA Tamariki trial. Future studies should explore the role of trusting relationships between researchers and treating clinicians when conducting research.
dc.format.extent195-
dc.identifier10.1186/s12887-022-03230-4
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/35410322
dc.identifier.citationTan E, Hoare K, Riley J, Fernando K, Haskell L, McKinlay CJ, Dalziel SR, Braithwaite I. (2022). Panic or peace - prioritising infant welfare when medicating feverish infants: a grounded theory study of adherence in a paediatric clinical trial.. BMC Pediatr. 22. 1. (pp. 195-).
dc.identifier.doi10.1186/s12887-022-03230-4
dc.identifier.eissn1471-2431
dc.identifier.elements-typejournal-article
dc.identifier.harvestedMassey_Dark
dc.identifier.issn1471-2431
dc.identifier.urihttp://hdl.handle.net/10179/19952
dc.languageeng
dc.publisherBioMed Central Ltd
dc.relation.isPartOfBMC Pediatr
dc.rights(c) The author/s CC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCOVID-19
dc.subjectConstructivist grounded theory
dc.subjectFever phobia
dc.subjectIbuprofen
dc.subjectPaediatric
dc.subjectParacetamol
dc.subjectTrial adherence
dc.subjectTrust
dc.subjectAcetaminophen
dc.subjectAsthma
dc.subjectFever
dc.subjectGrounded Theory
dc.subjectHumans
dc.subjectIbuprofen
dc.subjectInfant
dc.subjectInfant Welfare
dc.titlePanic or peace - prioritising infant welfare when medicating feverish infants: a grounded theory study of adherence in a paediatric clinical trial
dc.typeJournal article
pubs.elements-id452849
pubs.organisational-groupOther
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
452849.pdf
Size:
1.11 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Journal Articles