Protothecosis in four dogs in New Zealand.

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dc.citation.issue6
dc.citation.volume71
dc.contributor.authorPrice PSA
dc.contributor.authorKlobukowska HJ
dc.contributor.authorCastillo-Alcala F
dc.contributor.authorFoxwell JA
dc.contributor.authorOrbell GMB
dc.contributor.authorBrown S
dc.contributor.authorIrving AC
dc.coverage.spatialEngland
dc.date.accessioned2024-08-06T01:31:39Z
dc.date.available2024-08-06T01:31:39Z
dc.date.issued2023-09-04
dc.description.abstractCASE HISTORIES: Medical records of four dogs diagnosed with protothecosis in New Zealand were reviewed. The dogs were aged between 4 and 9 years and three of the four dogs were female. Breeds were one Labrador, one Miniature Schnauzer and two crossbreeds. The reasons for initial veterinary evaluation were a cough and opaque appearance of the right eye (Case 1), diarrhoea (Cases 2 and 3), and cutaneous disease (Case 4). CLINICAL FINDINGS: The ocular signs were characterised by panuveitis, retinal detachment and secondary glaucoma. Gastrointestinal signs included chronic haemorrhagic diarrhoea due to colitis. Three cases had disseminated infection and developed both bilateral, blinding, ocular disease and chronic gastrointestinal disease. Cutaneous signs consisted of draining fistulae over the olecranon, multifocal cutaneous nodules, and ulceration and tracts of the foot pads. Disseminated protothecosis was confirmed by histopathology of biopsied ocular tissues in Cases 1 and 2 and by gastrointestinal biopsies in Case 3. Prototheca spp. were also identified in cytological specimens from Cases 1 and 4 and recovered by culture in Cases 2 and 4. Cutaneous protothecosis was diagnosed in Case 4 initially by cytology and histopathology of skin lesions, and Prototheca zopfii was confirmed by PCR of cultured organisms. TREATMENT AND OUTCOME: Prior to diagnosis of protothecosis, a variety of treatments were prescribed to treat the gastrointestinal and ocular signs. After diagnosis, only Cases 2 and 4 received medication aimed at treating the protothecal infection, which was itraconazole in both cases. Following the progression of clinical signs and concerns about quality of life, all four dogs were euthanised. DIAGNOSIS: Disseminated protothecosis in three dogs, cutaneous protothecosis in one dog. CLINICAL RELEVANCE: Canine protothecosis is rarely reported, despite the ubiquity of the causal algae, and the disease usually carries an extremely grave prognosis when infection is generalised. In New Zealand, protothecosis should be considered as a differential diagnosis in dogs with panuveitis, chorioretinitis or retinal detachment, colitis, or nodular, ulcerative or fistulating cutaneous lesions.
dc.description.confidentialfalse
dc.edition.edition2023
dc.format.pagination321-328
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37584100
dc.identifier.citationPrice P, Klobukowska HJ, Castillo-Alcala F, Foxwell JA, Orbell G, Brown S, Irving AC. (2023). Protothecosis in four dogs in New Zealand.. N Z Vet J. 71. 6. (pp. 321-328).
dc.identifier.doi10.1080/00480169.2023.2248066
dc.identifier.eissn1176-0710
dc.identifier.elements-typejournal-article
dc.identifier.issn0048-0169
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71206
dc.languageeng
dc.publisherTaylor and Francis Group
dc.publisher.urihttps://www.tandfonline.com/doi/full/10.1080/00480169.2023.2248066
dc.relation.isPartOfN Z Vet J
dc.rights(c) 2023 The Author/s
dc.rightsCC BY-NC-ND 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectPrototheca
dc.subjectchorioretinitis
dc.subjectcolitis
dc.subjectcutaneous nodules
dc.subjectfoot pad ulceration
dc.subjectpanuveitis
dc.subjectprotothecosis
dc.subjectretinal detachment
dc.subjectDogs
dc.subjectAnimals
dc.subjectFemale
dc.subjectMale
dc.subjectInfections
dc.subjectRetinal Detachment
dc.subjectNew Zealand
dc.subjectQuality of Life
dc.subjectPlant Breeding
dc.subjectColitis
dc.subjectPanuveitis
dc.subjectDog Diseases
dc.subjectPrototheca
dc.titleProtothecosis in four dogs in New Zealand.
dc.typeJournal article
pubs.elements-id479923
pubs.organisational-groupOther
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