Social determinants and lifestyle factors for brain health: implications for risk reduction of cognitive decline and dementia

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dc.citation.issue1
dc.citation.volume12
dc.contributor.authorRöhr S
dc.contributor.authorPabst A
dc.contributor.authorBaber R
dc.contributor.authorEngel C
dc.contributor.authorGlaesmer H
dc.contributor.authorHinz A
dc.contributor.authorSchroeter ML
dc.contributor.authorWitte AV
dc.contributor.authorZeynalova S
dc.contributor.authorVillringer A
dc.contributor.authorLöffler M
dc.contributor.authorRiedel-Heller SG
dc.coverage.spatialEngland
dc.date.accessioned2024-01-08T23:50:30Z
dc.date.accessioned2024-07-25T06:32:42Z
dc.date.available2022-07-28
dc.date.available2024-01-08T23:50:30Z
dc.date.available2024-07-25T06:32:42Z
dc.date.issued2022-07-28
dc.description.abstractSubstantial evidence indicates a huge potential for risk reduction of cognitive decline and dementia based on modifiable health and lifestyle factors. To maximize the chances for risk reduction, it is useful to investigate associations of social determinants and lifestyle for brain health. We computed the “LIfestyle for BRAin health” (LIBRA) score for baseline participants of the Leipzig Research Centre for Civilization Diseases (LIFE) Adult Study, a population-based urban cohort in Germany. LIBRA predicts dementia in midlife and early late life populations, comprising 12 modifiable risk factors (heart disease, kidney disease, diabetes, obesity, hypertension, hypercholesterolemia, alcohol consumption, smoking, physical inactivity, diet, depression, cognitive inactivity). Associations of social determinants (living situation, marital status, social isolation, education, net equivalence income, occupational status, socioeconomic status/SES, employment) with LIBRA were inspected using age- and sex-adjusted multivariable linear regression analysis. Z-standardization and sampling weights were applied. Participants (n = 6203) were M = 57.4 (SD = 10.6, range 40–79) years old and without dementia, 53.0% were women. Except for marital status, all considered social determinants were significantly associated with LIBRA. Beta coefficients for the association with higher LIBRA scores were most pronounced for low SES (β = 0.80, 95% CI [0.72–0.88]; p < 0.001) and middle SES (β = 0.55, 95% CI [0.47–0.62]; p < 0.001). Social determinants, particularly socioeconomic factors, are associated with lifestyle for brain health, and should thus be addressed in risk reduction strategies for cognitive decline and dementia. A social-ecological public health perspective on risk reduction might be more effective and equitable than focusing on individual lifestyle behaviors alone.
dc.format.pagination12965-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/35902604
dc.identifier.citationRöhr S, Pabst A, Baber R, Engel C, Glaesmer H, Hinz A, Schroeter ML, Witte AV, Zeynalova S, Villringer A, Löffler M, Riedel-Heller SG. (2022). Social determinants and lifestyle factors for brain health: implications for risk reduction of cognitive decline and dementia.. Sci Rep. 12. 1. (pp. 12965-).
dc.identifier.doi10.1038/s41598-022-16771-6
dc.identifier.eissn2045-2322
dc.identifier.elements-typejournal-article
dc.identifier.issn2045-2322
dc.identifier.pii10.1038/s41598-022-16771-6
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70387
dc.languageeng
dc.publisherSpringer Nature Limited
dc.relation.isPartOfSci Rep
dc.rights(c) The author/sen
dc.rights.licenseCC BY 4.0en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectAdult
dc.subjectAged
dc.subjectBrain
dc.subjectCognitive Dysfunction
dc.subjectDementia
dc.subjectFemale
dc.subjectHumans
dc.subjectLife Style
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectRisk Factors
dc.subjectRisk Reduction Behavior
dc.subjectSocial Determinants of Health
dc.titleSocial determinants and lifestyle factors for brain health: implications for risk reduction of cognitive decline and dementia
dc.typeJournal article
pubs.elements-id455067
pubs.organisational-groupOther
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