Osteoinductive squamous cell carcinoma associated with a putative novel papillomavirus on the digit of a cat.

Simple item page
dc.citation.issue2
dc.citation.volume72
dc.contributor.authorMunday JS
dc.contributor.authorDunbar ME
dc.contributor.authorWightman P
dc.contributor.authorPiripi S
dc.coverage.spatialEngland
dc.date.accessioned2024-07-31T03:05:08Z
dc.date.available2024-07-31T03:05:08Z
dc.date.issued2024-03-01
dc.description.abstractCASE HISTORY AND CLINICAL FINDINGS: An approximately 10-year-old, castrated male domestic short-haired cat developed swelling and ulceration of the second digit of the right front paw. Radiographs revealed a spherical soft tissue swelling with irregular distal margins that contained multiple lacy mineral opacities. The digit was amputated and submitted for histology. No recurrence has been observed 7 months after amputation. PATHOLOGICAL AND MOLECULAR FINDINGS: Histology revealed a moderately well-circumscribed proliferation of well-differentiated squamous cells arranged in trabeculae and nests. Numerous thin spicules of osseous metaplasia were visible throughout the neoplasm. Around 70% of the neoplastic cells contained papillomavirus-induced cell changes including large amphophilic cytoplasmic bodies and cells with shrunken nuclei surrounded by a clear halo. Intense p16CDKN2A protein immunostaining was visible within the neoplastic cells, suggesting papillomavirus-induced changes in cell regulation. A DNA sequence from a putative novel Taupapillomavirus type was amplified from the neoplasm. DIAGNOSIS: Osteoinductive squamous cell carcinoma associated with a putative novel papillomavirus type. CLINICAL RELEVANCE: The findings in this case increase the number of papillomavirus types known to infect cats, and the squamous cell carcinoma had histological features that have not been previously reported. The neoplasm was not as invasive as is typical for a squamous cell carcinoma and excision appeared curative. This is the first report of an osteoinductive squamous cell carcinoma of the skin of cats and the neoplasm had a unique radiographic appearance.
dc.description.confidentialfalse
dc.edition.edition2024
dc.format.pagination112-117
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/38043925
dc.identifier.citationMunday JS, Dunbar ME, Wightman P, Piripi S. (2024). Osteoinductive squamous cell carcinoma associated with a putative novel papillomavirus on the digit of a cat.. N Z Vet J. 72. 2. (pp. 112-117).
dc.identifier.doi10.1080/00480169.2023.2285294
dc.identifier.eissn1176-0710
dc.identifier.elements-typejournal-article
dc.identifier.issn0048-0169
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71171
dc.languageeng
dc.publisherTaylor and Francis Group
dc.publisher.urihttps://www.tandfonline.com/doi/full/10.1080/00480169.2023.2285294
dc.relation.isPartOfN Z Vet J
dc.rights(c) 2023 The Author/s
dc.rightsCC BY-NC-ND 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCat
dc.subjectdermatology
dc.subjectneoplasia
dc.subjectnovel virus
dc.subjectpapillomavirus
dc.subjectskin
dc.subjectsquamous cell carcinoma
dc.subjectMale
dc.subjectAnimals
dc.subjectCarcinoma, Squamous Cell
dc.subjectSkin Neoplasms
dc.subjectSkin
dc.subjectPapillomaviridae
dc.subjectPapillomavirus Infections
dc.titleOsteoinductive squamous cell carcinoma associated with a putative novel papillomavirus on the digit of a cat.
dc.typeJournal article
pubs.elements-id485146
pubs.organisational-groupOther
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Published version.pdf
Size:
2.16 MB
Format:
Adobe Portable Document Format
Description:
485146 PDF.pdf
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
9.22 KB
Format:
Plain Text
Description:
Download
Collections
Journal Articles