Carriage of Extended-Spectrum-Beta-Lactamase- and AmpC Beta-Lactamase-Producing Escherichia coli Strains from Humans and Pets in the Same Households.

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dc.citation.issue24
dc.citation.volume86
dc.contributor.authorToombs-Ruane LJ
dc.contributor.authorBenschop J
dc.contributor.authorFrench NP
dc.contributor.authorBiggs PJ
dc.contributor.authorMidwinter AC
dc.contributor.authorMarshall JC
dc.contributor.authorChan M
dc.contributor.authorDrinković D
dc.contributor.authorFayaz A
dc.contributor.authorBaker MG
dc.contributor.authorDouwes J
dc.contributor.authorRoberts MG
dc.contributor.authorBurgess SA
dc.date.available2020-12
dc.date.available2020-09-29
dc.date.issued24/11/2020
dc.description.abstractExtended-spectrum-beta-lactamase (ESBL)- or AmpC beta-lactamase (ACBL)-producing Escherichia coli bacteria are the most common cause of community-acquired multidrug-resistant urinary tract infections (UTIs) in New Zealand. The carriage of antimicrobial-resistant bacteria has been found in both people and pets from the same household; thus, the home environment may be a place where antimicrobial-resistant bacteria are shared between humans and pets. In this study, we sought to determine whether members (pets and people) of the households of human index cases with a UTI caused by an ESBL- or ACBL-producing E. coli strain also carried an ESBL- or ACBL-producing Enterobacteriaceae strain and, if so, whether it was a clonal match to the index case clinical strain. Index cases with a community-acquired UTI were recruited based on antimicrobial susceptibility testing of urine isolates. Fecal samples were collected from 18 non-index case people and 36 pets across 27 households. Eleven of the 27 households screened had non-index case household members (8/18 people and 5/36 animals) positive for ESBL- and/or ACBL-producing E. coli strains. Whole-genome sequence analysis of 125 E. coli isolates (including the clinical urine isolates) from these 11 households showed that within seven households, the same strain of ESBL-/ACBL-producing E. coli was cultured from both the index case and another person (5/11 households) or pet dog (2/11 households). These results suggest that transmission within the household may contribute to the community spread of ESBL- or ACBL-producing E. coliIMPORTANCEEnterobacteriaceae that produce extended-spectrum beta-lactamases (ESBLs) and AmpC beta-lactamases (ACBLs) are important pathogens and can cause community-acquired illnesses, such as urinary tract infections (UTIs). Fecal carriage of these resistant bacteria by companion animals may pose a risk for transmission to humans. Our work evaluated the sharing of ESBL- and ACBL-producing E. coli isolates between humans and companion animals. We found that in some households, dogs carried the same strain of ESBL-producing E. coli as the household member with a UTI. This suggests that transmission events between humans and animals (or vice versa) are likely occurring within the home environment and, therefore, the community as a whole. This is significant from a health perspective, when considering measures to minimize community transmission, and highlights that in order to manage community spread, we need to consider interventions at the household level.
dc.description.publication-statusPublished
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000596591800013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifierARTN e01613-20
dc.identifier.citationAPPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2020, 86 (24)
dc.identifier.doi10.1128/AEM.01613-20
dc.identifier.eissn1098-5336
dc.identifier.elements-id435277
dc.identifier.harvestedMassey_Dark
dc.identifier.issn0099-2240
dc.identifier.urihttps://hdl.handle.net/10179/16042
dc.publisherAmerican Society for Microbiology
dc.relation.isPartOfAPPLIED AND ENVIRONMENTAL MICROBIOLOGY
dc.subjectESBL
dc.subjectEnterobacteriaceae
dc.subjectEscherichia coli
dc.subjectantibiotic resistance
dc.titleCarriage of Extended-Spectrum-Beta-Lactamase- and AmpC Beta-Lactamase-Producing Escherichia coli Strains from Humans and Pets in the Same Households.
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Health
pubs.organisational-group/Massey University/College of Health/Research Centre for Hauora and Health
pubs.organisational-group/Massey University/College of Sciences
pubs.organisational-group/Massey University/College of Sciences/NZ Institute of Advanced Studies
pubs.organisational-group/Massey University/College of Sciences/School of Mathematical and Computational Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Natural and Computational Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Natural and Computational Sciences/NZ Institute of Advanced Studies
pubs.organisational-group/Massey University/College of Sciences/School of Natural Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Veterinary Science
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