Nicotine exacerbates exertional heat strain in trained men: A randomized, placebo-controlled, double-blind study.

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dc.citation.issue2
dc.citation.volume137
dc.contributor.authorMoyen NE
dc.contributor.authorBarnes MJ
dc.contributor.authorPerry BG
dc.contributor.authorFujii N
dc.contributor.authorAmano T
dc.contributor.authorKondo N
dc.contributor.authorMundel T
dc.coverage.spatialUnited States
dc.date.accessioned2025-02-09T22:25:30Z
dc.date.available2025-02-09T22:25:30Z
dc.date.issued2024-08-16
dc.description.abstractTo determine whether using nicotine exacerbates exertional heat strain through an increased metabolic heat production (Hprod) or decreased skin blood flow (SkBF), 10 nicotine-naïve trained males [37 ± 12 yr; peak oxygen consumption (V̇o2peak): 66 ± 10 mL·min−1·kg−1] completed four trials at 20°C and 30°C following overnight transdermal nicotine (7 mg·24 h−1) and placebo use in a crossover, double-blind design. They cycled for 60 min (55% V̇o2peak) followed by a time trial (∼75% V̇o2peak) during which measures of gastrointestinal (Tgi) and mean weighted skin (̅Tsk) temperatures, SkBF, Hprod, and mean arterial pressure (MAP) were made. The difference in ΔTgi between nicotine and placebo trials was greater during 30°C (0.4 ± 0.5°C) than 20°C (0.1 ± 0.7°C), with ̅Tsk higher during nicotine than placebo trials (0.5 ± 0.5°C, P = 0.02). SkBF became progressively lower during nicotine than placebo trials (P = 0.01) and progressively higher during 30°C than 20°C trials (P < 0.01); MAP increased from baseline (P < 0.01) and remained elevated in all trials. The difference in Hprod between 30°C and 20°C trials was lower during nicotine than placebo (P = 0.01) and became progressively higher during 30°C than 20°C trials with exercise duration (P = 0.03). Mean power output during the time trial was lower during 30°C than 20°C trials (24 ± 25 W, P = 0.02), and although no effect of nicotine was observed (P > 0.59), two participants (20%) were unable to complete their 30°C nicotine trials as one reached the ethical limit for Tgi (40.0°C), whereas the other withdrew due to “nausea and chills” (Tgi = 39.7°C). These results demonstrate that nicotine use increases thermal strain and risk of exertional heat exhaustion by reducing SkBF. NEW & NOTEWORTHY In naïve participants, acute nicotine use exerts a hyperthermic effect that increases the risk of heat exhaustion during exertional heat strain, which is driven by a blunted skin blood flow response. This has implications for 1) populations that face exertional heat strain and demonstrate high nicotine use (e.g., athletes and military, 25%–50%) and 2) study design whereby screening and exclusion for nicotine use or standardization of prior use (e.g., overnight abstinence) is encouraged.
dc.description.confidentialfalse
dc.edition.editionAug 2024
dc.format.pagination421-428
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/38961822
dc.identifier.citationMoyen NE, Barnes MJ, Perry BG, Fujii N, Amano T, Kondo N, Mündel T. (2024). Nicotine exacerbates exertional heat strain in trained men: a randomized, placebo-controlled, double-blind study.. J Appl Physiol (1985). 137. 2. (pp. 421-428).
dc.identifier.doi10.1152/japplphysiol.00403.2024
dc.identifier.eissn1522-1601
dc.identifier.elements-typejournal-article
dc.identifier.issn8750-7587
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/72465
dc.languageeng
dc.publisherAmerican Physiological Society
dc.publisher.urihttps://journals.physiology.org/doi/abs/10.1152/japplphysiol.00403.2024
dc.relation.isPartOfJ Appl Physiol (1985)
dc.rights(c) 2024 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.en
dc.subjectexercise
dc.subjectheat stress
dc.subjectmetabolic heat production
dc.subjectnicotine
dc.subjectskin blood flow
dc.subjectHumans
dc.subjectMale
dc.subjectNicotine
dc.subjectDouble-Blind Method
dc.subjectAdult
dc.subjectCross-Over Studies
dc.subjectOxygen Consumption
dc.subjectSkin
dc.subjectHot Temperature
dc.subjectPhysical Exertion
dc.subjectMiddle Aged
dc.subjectSkin Temperature
dc.subjectExercise
dc.subjectHeat Stress Disorders
dc.subjectThermogenesis
dc.subjectRegional Blood Flow
dc.titleNicotine exacerbates exertional heat strain in trained men: A randomized, placebo-controlled, double-blind study.
dc.typeJournal article
pubs.elements-id489659
pubs.organisational-groupOther
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