Genome-wide association studies for citric and lactic acids in dairy sheep milk in a New Zealand flock

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dc.citation.issue1
dc.citation.volume35
dc.contributor.authorZongqi A
dc.contributor.authorMarshall AC
dc.contributor.authorJayawardana JMDR
dc.contributor.authorWeeks M
dc.contributor.authorLoveday SM
dc.contributor.authorMcNabb W
dc.contributor.authorLopez-Villalobos N
dc.coverage.spatialEngland
dc.date.accessioned2024-10-18T00:08:19Z
dc.date.available2024-10-18T00:08:19Z
dc.date.issued2024-08-05
dc.description.abstractThe objectives of this study were to estimate genetic parameters for citric acid content (CA) and lactic acid content (LA) in sheep milk and to identify the associated candidate genes in a New Zealand dairy sheep flock. Records from 165 ewes were used. Heritability estimates based on pedigree records for CA and LA were 0.65 and 0.33, respectively. The genetic and phenotypic correlations between CA and LA were strong-moderate and negative. Estimates of genomic heritability for CA and LA were also high (0.85, 0.51) and the genomic correlation between CA and LA was strongly negative (-0.96 ± 0.11). No significant associations were found at the Bonferroni level. However, one intragenic SNP in C1QTNF1 (chromosome 11) was associated with CA, at the chromosomal significance threshold. Another SNP associated with CA was intergenic (chromosome 15). For LA, the most notable SNP was intragenic in CYTH1 (chromosome 11), the other two SNPs were intragenic in MGAT5B and TIMP2 (chromosome 11), and four SNPs were intergenic (chromosomes 1 and 24). The functions of candidate genes indicate that CA and LA could potentially be used as biomarkers for energy balance and clinical mastitis. Further research is recommended to validate the present results.
dc.description.confidentialfalse
dc.format.pagination2379897-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/39102232
dc.identifier.citationZongqi A, Marshall AC, Jayawardana JMDR, Weeks M, Loveday SM, McNabb W, Lopez-Villalobos N. (2024). Genome-wide association studies for citric and lactic acids in dairy sheep milk in a New Zealand flock.. Anim Biotechnol. 35. 1. (pp. 2379897-).
dc.identifier.doi10.1080/10495398.2024.2379897
dc.identifier.eissn1532-2378
dc.identifier.elements-typejournal-article
dc.identifier.issn1049-5398
dc.identifier.number2379897
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71756
dc.languageeng
dc.publisherTaylor and Francis Group
dc.publisher.urihttps://www.tandfonline.com/doi/full/10.1080/10495398.2024.2379897
dc.relation.isPartOfAnim Biotechnol
dc.rights(c) 2024 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectSheep milk
dc.subjectcitric acid
dc.subjectgenome-wide-association study
dc.subjectlactic acid
dc.subjectAnimals
dc.subjectMilk
dc.subjectFemale
dc.subjectSheep
dc.subjectNew Zealand
dc.subjectGenome-Wide Association Study
dc.subjectPolymorphism, Single Nucleotide
dc.subjectCitric Acid
dc.subjectLactic Acid
dc.titleGenome-wide association studies for citric and lactic acids in dairy sheep milk in a New Zealand flock
dc.typeJournal article
pubs.elements-id491021
pubs.organisational-groupOther
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