Prevalence of the ABCB1-1Δ gene mutation in a sample of New Zealand Huntaway dogs

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dc.citation.issue3
dc.citation.volume71
dc.contributor.authorGedye K
dc.contributor.authorPoole-Crowe E
dc.contributor.authorShepherd M
dc.contributor.authorWilding A
dc.contributor.authorParton K
dc.contributor.authorLopez-Villalobos N
dc.contributor.authorCave N
dc.coverage.spatialEngland
dc.date.accessioned2024-12-04T02:33:43Z
dc.date.available2024-12-04T02:33:43Z
dc.date.issued2023-03-13
dc.description.abstractAIMS: To determine the prevalence of the ATP Binding Cassette Subfamily B Member 1-1Δ mutation (ABCB1-1Δ; previously Multidrug Resistance 1 (MDR1) mutation) in a cohort of New Zealand Huntaway dogs. MATERIALS AND METHODS: Samples were opportunistically collected from Huntaway dogs (n = 189) from throughout New Zealand. Buccal swabs were collected from 42 Huntaways from the Wairarapa region and 147 blood samples from Huntaways from the Gisborne, Waikato, Manawatū/Whanganui, Hawkes Bay, Canterbury and Otago regions. DNA was extracted from all samples and tested for the presence of the ABCB1-1Δ allele. RESULTS: Of 189 Huntaway dogs that were tested, two were found to be heterozygous carriers of the ABCB1-1Δ allele and the remaining 187/189 dogs were homozygous for the wild type allele. No dogs homozygous for the mutation were identified. CONCLUSIONS AND CLINICAL RELEVANCE: The results of this study show that the ABCB1-1Δ allele is present in Huntaway dogs. The low prevalence in this convenience sample suggests that the prevalence of this allele in the Huntaway population is likely to be low. We recommend that veterinary clinicians discuss the potential for this mutation in Huntaways with dog owners including the clinical implications for dogs that are homozygous for the mutated allele and the potential for testing for the mutation, as they would do for other known mutations.
dc.description.confidentialfalse
dc.edition.edition2023
dc.format.pagination133-136
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/36786530
dc.identifier.citationGedye K, Poole-Crowe E, Shepherd M, Wilding A, Parton K, Lopez-Villalobos N, Cave N. (2023). Prevalence of the ABCB1-1Δ gene mutation in a sample of New Zealand Huntaway dogs.. N Z Vet J. 71. 3. (pp. 133-136).
dc.identifier.doi10.1080/00480169.2023.2181238
dc.identifier.eissn1176-0710
dc.identifier.elements-typejournal-article
dc.identifier.issn0048-0169
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/72192
dc.languageeng
dc.publisherInforma UK Limited, trading as Taylor & Francis Group
dc.publisher.urihttps://www.tandfonline.com/doi/full/10.1080/00480169.2023.2181238
dc.relation.isPartOfN Z Vet J
dc.rights(c) The author/sen
dc.rights.licenseCC BY-NC-NDen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectABCB1-1Δ
dc.subjectHuntaway
dc.subjectdog
dc.subjectmultiple drug resistance
dc.subjectprevalence
dc.subjectAnimals
dc.subjectATP Binding Cassette Transporter, Subfamily B, Member 1
dc.subjectMutation
dc.subjectNew Zealand
dc.subjectPrevalence
dc.subjectCohort Studies
dc.subjectWorking Dogs
dc.titlePrevalence of the ABCB1-1Δ gene mutation in a sample of New Zealand Huntaway dogs
dc.typeJournal article
pubs.elements-id459728
pubs.organisational-groupOther
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