Ankyrin2 is essential for neuronal morphogenesis and long-term courtship memory in Drosophila.

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dc.citation.issue1
dc.citation.volume16
dc.contributor.authorSchwartz S
dc.contributor.authorWilson SJ
dc.contributor.authorHale TK
dc.contributor.authorFitzsimons HL
dc.coverage.spatialEngland
dc.date.accessioned2024-07-23T01:43:37Z
dc.date.available2024-07-23T01:43:37Z
dc.date.issued2023-05-16
dc.description.abstractDysregulation of HDAC4 expression and/or nucleocytoplasmic shuttling results in impaired neuronal morphogenesis and long-term memory in Drosophila melanogaster. A recent genetic screen for genes that interact in the same molecular pathway as HDAC4 identified the cytoskeletal adapter Ankyrin2 (Ank2). Here we sought to investigate the role of Ank2 in neuronal morphogenesis, learning and memory. We found that Ank2 is expressed widely throughout the Drosophila brain where it localizes predominantly to axon tracts. Pan-neuronal knockdown of Ank2 in the mushroom body, a region critical for memory formation, resulted in defects in axon morphogenesis. Similarly, reduction of Ank2 in lobular plate tangential neurons of the optic lobe disrupted dendritic branching and arborization. Conditional knockdown of Ank2 in the mushroom body of adult Drosophila significantly impaired long-term memory (LTM) of courtship suppression, and its expression was essential in the γ neurons of the mushroom body for normal LTM. In summary, we provide the first characterization of the expression pattern of Ank2 in the adult Drosophila brain and demonstrate that Ank2 is critical for morphogenesis of the mushroom body and for the molecular processes required in the adult brain for the formation of long-term memories.
dc.description.confidentialfalse
dc.edition.edition2023
dc.format.pagination42-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37194019
dc.identifier.citationSchwartz S, Wilson SJ, Hale TK, Fitzsimons HL. (2023). Ankyrin2 is essential for neuronal morphogenesis and long-term courtship memory in Drosophila.. Mol Brain. 16. 1. (pp. 42-).
dc.identifier.doi10.1186/s13041-023-01026-w
dc.identifier.eissn1756-6606
dc.identifier.elements-typejournal-article
dc.identifier.issn1756-6606
dc.identifier.number42
dc.identifier.pii10.1186/s13041-023-01026-w
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70278
dc.languageeng
dc.publisherBioMed Central Ltd
dc.publisher.urihttps://molecularbrain.biomedcentral.com/articles/10.1186/s13041-023-01026-w
dc.relation.isPartOfMol Brain
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectANK3
dc.subjectAnkyrin repeat
dc.subjectAnkyrin2
dc.subjectDrosophila
dc.subjectHDAC4
dc.subjectHistone deacetylase
dc.subjectMemory
dc.subjectMushroom body
dc.subjectNeuron
dc.subjectAnimals
dc.subjectAnkyrins
dc.subjectCourtship
dc.subjectDrosophila melanogaster
dc.subjectDrosophila Proteins
dc.subjectMemory, Long-Term
dc.subjectMorphogenesis
dc.subjectMushroom Bodies
dc.subjectNeurons
dc.titleAnkyrin2 is essential for neuronal morphogenesis and long-term courtship memory in Drosophila.
dc.typeJournal article
pubs.elements-id461679
pubs.organisational-groupOther
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