The association between fluoride concentrations and spontaneous humeral fracture in first-lactation dairy cows: results from two New Zealand studies

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dc.citation.volumeLatest Articles
dc.contributor.authorWehrle-Martinez A
dc.contributor.authorDittmer KE
dc.contributor.authorBack PJ
dc.contributor.authorRogers CW
dc.contributor.authorWeston JF
dc.contributor.authorJeyakumar P
dc.contributor.authorPereira RV
dc.contributor.authorPoppenga R
dc.contributor.authorTaylor HS
dc.contributor.authorLawrence KE
dc.coverage.spatialEngland
dc.date.accessioned2025-01-08T19:43:13Z
dc.date.available2025-01-08T19:43:13Z
dc.date.issued2024-11-17
dc.description.abstractAIM: To assess whether the fluoride concentration in the humeri of first-lactation, 2-year-old dairy cows with a spontaneous humeral fracture is significantly different from that of first-lactation, 2-year-old dairy cows without a humeral fracture. METHODS: Two studies were conducted, the first with nine bone samples from 2-year-old, first-calving dairy cows with a humeral fracture (all from the Waikato region) age-matched with seven control bone samples from the Waikato, Bay of Plenty and Manawatū-Whanganui regions. The second study used 26 bone samples from 2-year-old, first-lactation dairy cows with a humeral fracture (from the Otago, Canterbury, Southland, West Coast, Waikato and Manawatū-Whanganui regions) age-matched with 14 control bone samples (all from the Manawatū-Whanganui region or unknown). Control bone samples were from first-lactation, 2-year-old dairy cows that did not have humeral fractures. Bone fluoride concentration was quantified for all samples. RESULTS: The median fluoride concentration of humeri from first-lactation, 2-year-old dairy cows with a humeral fracture was significantly higher than humeri from unaffected control cows in both studies. In Study 1, the median bone fluoride concentration was 599 (IQR 562.7-763.5) mg/kg from case cows and 296.6 (IQR: 191.2-391.7) mg/kg from control cows (p < 0.001), and in Study 2 the median bone fluoride concentration from case and control cows was 415 (IQR: 312.5-515) mg/kg and 290 (IQR: 262.5-410) mg/kg (p = 0.04) respectively. CONCLUSIONS AND CLINICAL RELEVANCE: Although there are limitations to this study due to the unbalanced regional distribution of cases and controls, the results indicate that sub-clinical fluoride toxicosis may be linked to spontaneous humeral fractures in first-lactation dairy cows in New Zealand. Further research is required to determine if bone fluoride concentrations play a role in the pathogenesis of these fractures.
dc.description.confidentialfalse
dc.edition.edition2024
dc.format.pagination1-5
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/39551477
dc.identifier.citationWehrle-Martinez A, Dittmer KE, Back PJ, Rogers CW, Weston JF, Jeyakumar P, Pereira RV, Poppenga R, Taylor HS, Lawrence KE. (2024). The association between fluoride concentrations and spontaneous humeral fracture in first-lactation dairy cows: results from two New Zealand studies.. N Z Vet J. Latest Articles. (pp. 1-5).
dc.identifier.doi10.1080/00480169.2024.2418929
dc.identifier.eissn1176-0710
dc.identifier.elements-typejournal-article
dc.identifier.issn0048-0169
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/72338
dc.languageeng
dc.publisherTaylor and Francis Group
dc.publisher.urihttps://www.tandfonline.com/doi/full/10.1080/00480169.2024.2418929
dc.relation.isPartOfN Z Vet J
dc.rights(c) 2024 The Author/s
dc.rightsCC BY-NC-ND 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectHumeral fracture
dc.subjectNew Zealand
dc.subjectbone
dc.subjectcows
dc.subjectfluoride
dc.titleThe association between fluoride concentrations and spontaneous humeral fracture in first-lactation dairy cows: results from two New Zealand studies
dc.typeJournal article
pubs.elements-id492323
pubs.organisational-groupOther
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