Hydrogen cross-feeders of the human gastrointestinal tract.
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Date
2019-01-01
Open Access Location
Authors
Journal Title
Journal ISSN
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Publisher
Taylor & Francis Group
Rights
(c) 2018 The Author/s
CC BY-NC-ND 4.0
CC BY-NC-ND 4.0
Abstract
Hydrogen plays a key role in many microbial metabolic pathways in the human gastrointestinal tract (GIT) that have an impact on human nutrition, health and wellbeing. Hydrogen is produced by many members of the GIT microbiota, and may be subsequently utilized by cross-feeding microbes for growth and in the production of larger molecules. Hydrogenotrophic microbes fall into three functional groups: sulfate-reducing bacteria, methanogenic archaea and acetogenic bacteria, which can convert hydrogen into hydrogen sulfide, methane and acetate, respectively. Despite different energy yields per molecule of hydrogen used between the functional groups, all three can coexist in the human GIT. The factors affecting the numerical balance of hydrogenotrophs in the GIT remain unconfirmed. There is increasing evidence linking both hydrogen sulfide and methane to GIT diseases such as irritable bowel syndrome, and strategies for the mitigation of such health problems through targeting of hydrogenotrophs constitute an important field for further investigation.
Description
Keywords
bacteria, colorectal cancer, cross-feeding, gastrointestinal, inflammatory bowel disease, irritable bowel syndrome, methane, microbiota, sulfate-reducing bacteria, sulfide, Acetates, Animals, Archaea, Bacteria, Gastrointestinal Diseases, Gastrointestinal Microbiome, Humans, Hydrogen, Hydrogen Sulfide, Methane
Citation
Smith NW, Shorten PR, Altermann EH, Roy NC, McNabb WC. (2019). Hydrogen cross-feeders of the human gastrointestinal tract.. Gut Microbes. 10. 3. (pp. 270-288).