The Role of Segmented Filamentous Bacteria in Immune Barrier Maturation of the Small Intestine at Weaning.

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dc.citation.volume8
dc.contributor.authorOemcke LA
dc.contributor.authorAnderson RC
dc.contributor.authorAltermann E
dc.contributor.authorRoy NC
dc.contributor.authorMcNabb WC
dc.contributor.editorDe Los Reyes-Gavilan CG
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-10-02T00:21:37Z
dc.date.available2024-10-02T00:21:37Z
dc.date.issued2021-11-18
dc.description.abstractThe microbiological, physical, chemical, and immunological barriers of the gastrointestinal tract (GIT) begin developing in utero and finish maturing postnatally. Maturation of these barriers is essential for the proper functioning of the GIT. Maturation, particularly of the immunological barrier, involves stimulation by bacteria. Segmented filamentous bacteria (SFB) which are anaerobic, spore-forming commensals have been linked to immune activation. The presence and changes in SFB abundance have been positively correlated to immune markers (cytokines and immunoglobulins) in the rat ileum and stool samples, pre- and post-weaning. The abundance of SFB in infant stool increases from 6 months, peaks around 12 months and plateaus 25 months post-weaning. Changes in SFB abundance at these times correlate positively and negatively with the production of interleukin 17 (IL 17) and immunoglobulin A (IgA), respectively, indicating involvement in immune function and maturation. Additionally, the peak in SFB abundance when a human milk diet was complemented by solid foods hints at a diet effect. SFB genome analysis revealed enzymes involved in metabolic pathways for survival, growth and development, host mucosal attachment and substrate acquisition. This narrative review discusses the current knowledge of SFB and their suggested effects on the small intestine immune system. Referencing the published genomes of rat and mouse SFB, the use of food substrates to modulate SFB abundance is proposed while considering their effects on other microbes. Changes in the immune response caused by the interaction of food substrate with SFB may provide insight into their role in infant immunological barrier maturation.
dc.description.confidentialfalse
dc.edition.edition2021
dc.format.pagination759137-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/34869529
dc.identifier.citationOemcke LA, Anderson RC, Altermann E, Roy NC, McNabb WC. (2021). The Role of Segmented Filamentous Bacteria in Immune Barrier Maturation of the Small Intestine at Weaning.. Front Nutr. 8. (pp. 759137-).
dc.identifier.doi10.3389/fnut.2021.759137
dc.identifier.eissn2296-861X
dc.identifier.elements-typejournal-article
dc.identifier.issn2296-861X
dc.identifier.number759137
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71559
dc.languageeng
dc.publisherFrontiers Media S.A.
dc.publisher.urihttps://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.759137/full
dc.relation.isPartOfFront Nutr
dc.rights(c) The author/sen
dc.rights.licenseCC BYen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectfood substrate
dc.subjectgastrointestinal tract
dc.subjectimmunoglobulin A
dc.subjectimmunological barrier
dc.subjectinterleukin 17
dc.subjectsegmented filamentous bacteria
dc.subjectweaning diet
dc.titleThe Role of Segmented Filamentous Bacteria in Immune Barrier Maturation of the Small Intestine at Weaning.
dc.typeJournal article
pubs.elements-id450090
pubs.organisational-groupOther
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