Selective treatment of nonsevere clinical mastitis does not adversely affect cure, somatic cell count, milk yield, recurrence, or culling: A systematic review and meta-analysis

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dc.citation.issue2
dc.citation.volume106
dc.contributor.authorde Jong E
dc.contributor.authorCreytens L
dc.contributor.authorDe Vliegher S
dc.contributor.authorMcCubbin KD
dc.contributor.authorBaptiste M
dc.contributor.authorLeung AA
dc.contributor.authorSpeksnijder D
dc.contributor.authorDufour S
dc.contributor.authorMiddleton JR
dc.contributor.authorRuegg PL
dc.contributor.authorLam TJGM
dc.contributor.authorKelton DF
dc.contributor.authorMcDougall S
dc.contributor.authorGodden SM
dc.contributor.authorLago A
dc.contributor.authorRajala-Schultz PJ
dc.contributor.authorOrsel K
dc.contributor.authorKrömker V
dc.contributor.authorKastelic JP
dc.contributor.authorBarkema HW
dc.coverage.spatialUnited States
dc.date.accessioned2024-02-02T01:48:00Z
dc.date.accessioned2024-07-25T06:53:25Z
dc.date.available2022-12-19
dc.date.available2024-02-02T01:48:00Z
dc.date.available2024-07-25T06:53:25Z
dc.date.issued2023-02
dc.description.abstractTreatment of clinical mastitis (CM) contributes to antimicrobial use on dairy farms. Selective treatment of CM based on bacterial diagnosis can reduce antimicrobial use, as not all cases of CM will benefit from antimicrobial treatment, e.g., mild and moderate gram-negative infections. However, impacts of selective CM treatment on udder health and culling are not fully understood. A systematic search identified 13 studies that compared selective versus blanket CM treatment protocols. Reported outcomes were synthesized with random-effects models and presented as risk ratios or mean differences. Selective CM treatment protocol was not inferior to blanket CM treatment protocol for the outcome bacteriological cure. Noninferiority margins could not be established for the outcomes clinical cure, new intramammary infection, somatic cell count, milk yield, recurrence, or culling. However, no differences were detected between selective and blanket CM treatment protocols using traditional analyses, apart from a not clinically relevant increase in interval from treatment to clinical cure (0.4 d) in the selective group and higher proportion of clinical cure at 14 d in the selective group. The latter occurred in studies co-administering nonsteroidal anti-inflammatories only in the selective group. Bias could not be ruled out in most studies due to suboptimal randomization, although this would likely only affect subjective outcomes such as clinical cure. Hence, findings were supported by a high or moderate certainty of evidence for all outcome measures except clinical cure. In conclusion, this review supported the assertion that a selective CM treatment protocol can be adopted without adversely influencing bacteriological and clinical cure, somatic cell count, milk yield, and incidence of recurrence or culling.
dc.description.confidentialfalse
dc.edition.editionFebruary 2023
dc.format.pagination1267-1286
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/36543640
dc.identifier.citationde Jong E, Creytens L, De Vliegher S, McCubbin KD, Baptiste M, Leung AA, Speksnijder D, Dufour S, Middleton JR, Ruegg PL, Lam TJGM, Kelton DF, McDougall S, Godden SM, Lago A, Rajala-Schultz PJ, Orsel K, Krömker V, Kastelic JP, Barkema HW. (2023). Selective treatment of nonsevere clinical mastitis does not adversely affect cure, somatic cell count, milk yield, recurrence, or culling: A systematic review and meta-analysis.. J Dairy Sci. 106. 2. (pp. 1267-1286).
dc.identifier.doi10.3168/jds.2022-22271
dc.identifier.eissn1525-3198
dc.identifier.elements-typejournal-article
dc.identifier.issn0022-0302
dc.identifier.piiS0022-0302(22)00733-0
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71109
dc.languageeng
dc.publisherElsevier Inc and The Federation of Animal Science Societies (Fass) Inc on behalf of the American Dairy Science Association
dc.publisher.urihttps://www.journalofdairyscience.org/article/S0022-0302(22)00733-0/fulltext
dc.relation.isPartOfJ Dairy Sci
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectantimicrobial stewardship
dc.subjectbacteriological cure
dc.subjectclinical mastitis
dc.subjectnoninferiority
dc.subjectrapid diagnostic test
dc.subjectCattle
dc.subjectFemale
dc.subjectAnimals
dc.subjectMilk
dc.subjectAnti-Bacterial Agents
dc.subjectMastitis, Bovine
dc.subjectAnti-Infective Agents
dc.subjectCell Count
dc.subjectMammary Glands, Animal
dc.subjectLactation
dc.subjectCattle Diseases
dc.titleSelective treatment of nonsevere clinical mastitis does not adversely affect cure, somatic cell count, milk yield, recurrence, or culling: A systematic review and meta-analysis
dc.typeJournal article
pubs.elements-id458722
pubs.organisational-groupOther
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