Genetic Variation in the Glycoprotein B Sequence of Equid Herpesvirus 5 among Horses of Various Breeds at Polish National Studs.

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dc.citation.issue3
dc.citation.volume10
dc.contributor.authorStasiak K
dc.contributor.authorDunowska M
dc.contributor.authorTrewick S
dc.contributor.authorRola J
dc.contributor.editorBodem J
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-01-11T20:25:22Z
dc.date.accessioned2024-07-25T06:50:11Z
dc.date.available2021-03-09
dc.date.available2024-01-11T20:25:22Z
dc.date.available2024-07-25T06:50:11Z
dc.date.issued2021-03-09
dc.description.abstractEquid herpesvirus 5 (EHV-5) is one of two γ-herpesviruses that commonly infect horses worldwide. The objective of the study was to estimate the genetic variability within EHV-5 viruses circulating among horses in Poland. Partial glycoprotein B (gB) sequences from 92 Polish horses from 13 studs throughout Poland were compared to each other and to three EHV-5 sequences from other countries. Despite the overall high level of conservation, considerable variability was observed around the putative furin cleavage site. Based on phylogenetic analysis, the viruses clustered within two major lineages (A and B), with further sub-clustering within group A. The clustering of EHV-5 sequences was independent of age or geographical origin of the sampled horses. Recombination was identified as one of the factors contributing to the genomic heterogeneity. Viruses from unweaned foals were more similar to viruses from other foals at the same stud than to viruses form their dams, suggesting the horizontal transfer and/or evolution of EHV-5 within individual hosts. Our data indicate that the gB sequence is not suitable for tracking the source of EHV-5 infection. Further research is needed to elucidate the importance of the sequence variability around the EHV-5 gB furin cleavage site on the biology of the virus.
dc.description.confidentialfalse
dc.edition.editionMarch 2021
dc.format.pagination322-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/33803246
dc.identifier.citationStasiak K, Dunowska M, Trewick S, Rola J. (2021). Genetic Variation in the Glycoprotein B Sequence of Equid Herpesvirus 5 among Horses of Various Breeds at Polish National Studs.. Pathogens. 10. 3. (pp. 322-).
dc.identifier.doi10.3390/pathogens10030322
dc.identifier.eissn2076-0817
dc.identifier.elements-typejournal-article
dc.identifier.issn2076-0817
dc.identifier.numberARTN 322
dc.identifier.piipathogens10030322
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70976
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2076-0817/10/3/322
dc.relation.isPartOfPathogens
dc.rights(c) The author/sen
dc.rights.licenseCC BY 4.0en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectequid herpesvirus 5
dc.subjectgenetic variability
dc.subjectglycoprotein B
dc.subjectphylogeny
dc.titleGenetic Variation in the Glycoprotein B Sequence of Equid Herpesvirus 5 among Horses of Various Breeds at Polish National Studs.
dc.typeJournal article
pubs.elements-id442579
pubs.organisational-groupOther
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