Genomic and clinical characteristics of campylobacteriosis in Australia.

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dc.citation.issue1
dc.citation.volume10
dc.contributor.authorCribb DM
dc.contributor.authorMoffatt CRM
dc.contributor.authorWallace RL
dc.contributor.authorMcLure AT
dc.contributor.authorBulach D
dc.contributor.authorJennison AV
dc.contributor.authorFrench N
dc.contributor.authorValcanis M
dc.contributor.authorGlass K
dc.contributor.authorKirk MD
dc.coverage.spatialEngland
dc.date.accessioned2024-08-11T23:12:40Z
dc.date.available2024-08-11T23:12:40Z
dc.date.issued2024-01
dc.description.abstractCampylobacter spp. are a common cause of bacterial gastroenteritis in Australia, primarily acquired from contaminated meat. We investigated the relationship between genomic virulence characteristics and the severity of campylobacteriosis, hospitalisation, and other host factors.We recruited 571 campylobacteriosis cases from three Australian states and territories (2018-2019). We collected demographic, health status, risk factors, and self-reported disease data. We whole genome sequenced 422 C. jejuni and 84 C. coli case isolates along with 616 retail meat isolates. We classified case illness severity using a modified Vesikari scoring system, performed phylogenomic analysis, and explored risk factors for hospitalisation and illness severity.On average, cases experienced a 7.5 day diarrhoeal illness with additional symptoms including stomach cramps (87.1 %), fever (75.6 %), and nausea (72.0 %). Cases aged ≥75 years had milder symptoms, lower Vesikari scores, and higher odds of hospitalisation compared to younger cases. Chronic gastrointestinal illnesses also increased odds of hospitalisation. We observed significant diversity among isolates, with 65 C. jejuni and 21 C. coli sequence types. Antimicrobial resistance genes were detected in 20.4 % of isolates, but multidrug resistance was rare (0.04 %). Key virulence genes such as cdtABC (C. jejuni) and cadF were prevalent (>90 % presence) but did not correlate with disease severity or hospitalisation. However, certain genes (e.g. fliK, Cj1136, and Cj1138) appeared to distinguish human C. jejuni cases from food source isolates.Campylobacteriosis generally presents similarly across cases, though some are more severe. Genotypic virulence factors identified in the literature to-date do not predict disease severity but may differentiate human C. jejuni cases from food source isolates. Host factors like age and comorbidities have a greater influence on health outcomes than virulence factors.
dc.description.confidentialfalse
dc.edition.edition2024
dc.format.pagination1-11
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/38214338
dc.identifier.citationCribb DM, Moffatt CRM, Wallace RL, McLure AT, Bulach D, Jennison AV, French N, Valcanis M, Glass K, Kirk MD. (2024). Genomic and clinical characteristics of campylobacteriosis in Australia.. Microb Genom. 10. 1. (pp. 1-11).
dc.identifier.doi10.1099/mgen.0.001174
dc.identifier.eissn2057-5858
dc.identifier.elements-typejournal-article
dc.identifier.issn2057-5858
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71259
dc.languageeng
dc.publisherMicrobiology Society
dc.publisher.urihttps://www.microbiologyresearch.org/content/journal/mgen/10.1099/mgen.0.001174
dc.relation.isPartOfMicrob Genom
dc.rights(c) 2024 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.en
dc.subjectCampylobacter
dc.subjectantimicrobial resistance
dc.subjectclinical outcomes
dc.subjectseverity
dc.subjectvirulence
dc.subjectwhole genome sequencing
dc.subjectHumans
dc.subjectCampylobacter Infections
dc.subjectCampylobacter jejuni
dc.subjectCampylobacter coli
dc.subjectAustralia
dc.subjectGastroenteritis
dc.subjectVirulence Factors
dc.subjectGenomics
dc.titleGenomic and clinical characteristics of campylobacteriosis in Australia.
dc.typeJournal article
pubs.elements-id485769
pubs.organisational-groupOther
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