Sports and trauma as risk factors for Motor Neurone Disease: New Zealand case-control study

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dc.citation.issue6
dc.citation.volume145
dc.contributor.authorChen GX
dc.contributor.authorDouwes J
dc.contributor.authorvan den Berg LH
dc.contributor.authorGlass B
dc.contributor.authorMcLean D
dc.contributor.author't Mannetje AM
dc.coverage.spatialDenmark
dc.date.accessioned2023-06-28T19:42:01Z
dc.date.available2022-03-18
dc.date.available2023-06-28T19:42:01Z
dc.date.issued2022-06
dc.description(c) The Author/s
dc.description.abstractOBJECTIVES: To assess whether sports, physical trauma and emotional trauma are associated with motor neurone disease (MND) in a New Zealand case-control study (2013-2016). METHODS: In total, 321 MND cases and 605 population controls were interviewed collecting information on lifetime histories of playing sports, physical trauma (head injury with concussion, spine injury) and emotional trauma (14 categories). ORs were estimated using logistic regression adjusting for age, sex, ethnicity, socioeconomic status, education, smoking status, alcohol consumption and mutually adjusting for all other exposures. RESULTS: Head injury with concussion ≥3 years before diagnosis was associated with MND (OR 1.51, 95% CI: 1.09-2.09), with strongest associations for two (OR 4.01, 95% CI: 1.82-8.86), and three or more (OR 2.34, 95% CI: 1.00-5.45) head injuries. Spine injury was not associated with MND (OR 0.81, 95% CI: 0.48-1.36). Compared to never playing sports, engaging in sports throughout childhood and adulthood increased MND risk (OR 1.81, 95% CI: 1.01-3.25), as was more than 12 years playing football/soccer (OR 2.35, 95% CI: 1.19-4.65). Reporting emotionally traumatic events in more than three categories was associated with MND (OR 1.88, 95% CI: 1.17-3.03), with physical childhood abuse the only specific emotional trauma associated with MND (OR 1.82, 95% CI: 1.14-2.90), particularly for those reporting longer abuse duration (OR(5-8 years) 2.26, 95% CI: 1.14-4.49; OR(>8 years) 3.01, 95% CI: 1.18-7.70). For females, having witnessed another person being killed, seriously injured or assaulted also increased MND risk (OR 2.68, 95% CI: 1.06-6.76). CONCLUSIONS: This study adds to the evidence that repeated head injury with concussion, playing sports in general, and playing football (soccer) in particular, are associated with an increased risk of MND. Emotional trauma, that is physical abuse in childhood, may also play a role.
dc.description.publication-statusPublished
dc.format.extent770 - 785
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/35355246
dc.identifier.citationActa Neurol Scand, 2022, 145 (6), pp. 770 - 785
dc.identifier.doi10.1111/ane.13615
dc.identifier.eissn1600-0404
dc.identifier.elements-id452663
dc.identifier.harvestedMassey_Dark
dc.identifier.urihttps://hdl.handle.net/10179/18362
dc.languageeng
dc.publisherJohn Wiley and Sons Ltd
dc.relation.isPartOfActa Neurol Scand
dc.subjectALS
dc.subjectemotional trauma
dc.subjecthead injury
dc.subjectneurodegenerative disorders
dc.subjectneuroepidemiology
dc.subjectAdult
dc.subjectAthletic Injuries
dc.subjectBrain Concussion
dc.subjectCase-Control Studies
dc.subjectChild
dc.subjectCraniocerebral Trauma
dc.subjectFemale
dc.subjectHumans
dc.subjectMotor Neuron Disease
dc.subjectNew Zealand
dc.subjectRisk Factors
dc.subject.anzsrc1103 Clinical Sciences
dc.titleSports and trauma as risk factors for Motor Neurone Disease: New Zealand case-control study
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Health
pubs.organisational-group/Massey University/College of Health/Research Centre for Hauora and Health
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