Identification of Felis catus papillomavirus 3 in skin neoplasms from four cats.

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dc.citation.issue2
dc.citation.volume30
dc.contributor.authorMunday JS
dc.contributor.authorThomson NA
dc.contributor.authorHenderson G
dc.contributor.authorFairley R
dc.contributor.authorOrbell GM
dc.date.available2018-03
dc.date.issued2018-03
dc.description.abstractBowenoid in situ carcinomas (BISCs) are papillomavirus (PV)-induced skin neoplasms that are thought to be caused by Felis catus papillomavirus (FcaPV) 2. As BISCs are typically multiple and can become extensive, they can be difficult to treat. Herein we describe 4 cats that developed skin neoplasms that contained FcaPV-3 DNA. One cat developed multiple basal cell carcinomas (BCCs), 1 a BISC with unusual extension into hair follicles, and 2 developed a single typical-appearing BISC. All neoplasms contained prominent PV-induced cell changes and intense p16CDKN2a protein immunostaining. Results from these 4 cats provide evidence that FcaPV-3 could cause a proportion of feline skin cancers, albeit less frequently than FcaPV-2. Excision of the typical BISCs and the BCCs appeared curative. Although the cat with the unusual BISC was euthanized because of the large size of the lesion, evidence from these 4 cats suggests that skin neoplasms that contain FcaPV-3 DNA may have a less aggressive clinical behavior than those associated with FcaPV-2. A consistent feature of the neoplasms in all 4 cats was the presence of prominent basophilic intracytoplasmic inclusion bodies; these inclusions have not been reported in lesions caused by FcaPV-2, to our knowledge, and their detection may allow differentiation between the different PV types and could therefore be a useful prognostic feature.
dc.description.publication-statusPublished
dc.format.extent324 - 328
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000424217100026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifier.citationJOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 2018, 30 (2), pp. 324 - 328
dc.identifier.doi10.1177/1040638717750852
dc.identifier.eissn1943-4936
dc.identifier.elements-id398289
dc.identifier.harvestedMassey_Dark
dc.identifier.issn1040-6387
dc.identifier.urihttps://hdl.handle.net/10179/14718
dc.relation.isPartOfJOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
dc.subjectBasal cell carcinoma
dc.subjectBowenoid in situ carcinoma
dc.subjectcats
dc.subjectpapillomavirus
dc.subjectskin cancer
dc.subjectviral oncogenesis
dc.subject.anzsrc0608 Zoology
dc.subject.anzsrc0707 Veterinary Sciences
dc.titleIdentification of Felis catus papillomavirus 3 in skin neoplasms from four cats.
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Veterinary Science
pubs.organisational-group/Massey University/Other
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