Peripheral astral microtubules ensure asymmetric furrow positioning in neural stem cells

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dc.citation.issue4
dc.citation.volume37
dc.contributor.authorThomas A
dc.contributor.authorGallaud E
dc.contributor.authorPascal A
dc.contributor.authorSerre L
dc.contributor.authorArnal I
dc.contributor.authorRichard-Parpaillon L
dc.contributor.authorSavoian MS
dc.contributor.authorGiet R
dc.coverage.spatialUnited States
dc.date.accessioned2024-01-11T22:43:26Z
dc.date.accessioned2024-07-25T06:40:22Z
dc.date.available2021-10-26
dc.date.available2024-01-11T22:43:26Z
dc.date.available2024-07-25T06:40:22Z
dc.date.issued2021-10-26
dc.description.abstractNeuroblast division is characterized by asymmetric positioning of the cleavage furrow, resulting in a large difference in size between the future daughter cells. In animal cells, furrow placement and assembly are governed by centralspindlin that accumulates at the equatorial cell cortex of the future cleavage site and at the spindle midzone. In neuroblasts, these two centralspindlin populations are spatially and temporally separated. A leading pool is located at the basal cleavage site and a second pool accumulates at the midzone before traveling to the cleavage site. The cortical centralspindlin population requires peripheral astral microtubules and the chromosome passenger complex for efficient recruitment. Loss of this pool does not prevent cytokinesis but enhances centralspindlin signaling at the midzone, leading to equatorial furrow repositioning and decreased size asymmetry. These data show that basal furrow positioning in neuroblasts results from a competition between different centralspindlin pools in which the cortical pool is dominant.
dc.description.confidentialfalse
dc.format.pagination109895-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/34706235
dc.identifier.citationThomas A, Gallaud E, Pascal A, Serre L, Arnal I, Richard-Parpaillon L, Savoian MS, Giet R. (2021). Peripheral astral microtubules ensure asymmetric furrow positioning in neural stem cells.. Cell Rep. 37. 4. (pp. 109895-).
dc.identifier.doi10.1016/j.celrep.2021.109895
dc.identifier.eissn2211-1247
dc.identifier.elements-typejournal-article
dc.identifier.issn2211-1247
dc.identifier.numberARTN 109895
dc.identifier.piiS2211-1247(21)01365-6
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70649
dc.languageeng
dc.publisherElsevier Inc
dc.publisher.urihttps://www.sciencedirect.com/science/article/pii/S2211124721013656
dc.relation.isPartOfCell Rep
dc.rights(c) The author/sen
dc.rights.licenseCC BY 4.0en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectCentralspindlin complex
dc.subjectDrosophila neural stem cell
dc.subjectasymmetric cell division
dc.subjectbasal furrow positioning
dc.subjectcell size
dc.subjectcentrosome
dc.subjectcytokinesis
dc.subjectmyosin
dc.subjectperipheral astral microtubules
dc.subjectspindle midzone
dc.subjectAnimals
dc.subjectCytokinesis
dc.subjectDrosophila melanogaster
dc.subjectMicrotubules
dc.subjectNeural Stem Cells
dc.titlePeripheral astral microtubules ensure asymmetric furrow positioning in neural stem cells
dc.typeJournal article
pubs.elements-id449326
pubs.organisational-groupOther
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