The Characterisation of Carbapenem-Resistant Acinetobacter baumannii and Klebsiella pneumoniae in a Teaching Hospital in Malaysia.

Simple item page
dc.citation.issue11
dc.citation.volume13
dc.contributor.authorLau MY
dc.contributor.authorPonnampalavanar S
dc.contributor.authorChong CW
dc.contributor.authorDwiyanto J
dc.contributor.authorLee YQ
dc.contributor.authorWoon JJ
dc.contributor.authorKong ZX
dc.contributor.authorJasni AS
dc.contributor.authorLee MCC
dc.contributor.authorObaidellah UH
dc.contributor.authorTeh CSJ
dc.contributor.editorChristodoulides M
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-12-12T01:20:55Z
dc.date.available2024-12-12T01:20:55Z
dc.date.issued2024-11-20
dc.description.abstractBackground/Objectives: The emergence and dissemination of carbapenem-resistant organisms, particularly Acinetobacter baumannii and Klebsiella pneumoniae, pose a significant threat to healthcare systems worldwide. This retrospective study aims to characterise carbapenem-resistant Acinetobacter baumannii (CRAB) and carbapenem-resistant Klebsiella pneumoniae (CRKP) strains in a teaching hospital and to determine the risk factors associated with patients' in-hospital mortality. Methods: A total of 90 CRAB and 63 CRKP were included in this study. Carbapenemase genes and MLST types of CRAB and CRKP were determined using specific primers. Risk factors associated with in-hospital mortality were analysed with collected data. Results: All the CRAB strains consisted of OXA carbapenemase genes, with 98% of the strains co-harbouring blaOXA-23-like and blaOXA-51-like carbapenemase genes. Conversely, blaNDM is the predominant carbapenemase gene in CRKP, followed by blaOXA-48-like carbapenemase genes. ST2 and ST20 are the dominant MLST types in CRAB and CRKP, respectively. In CRAB, multivariate analysis identified age, ethnicity, the presence of a mechanical ventilator, and patients who experienced previous exposure to clindamycin in the last 90 days as associated with an increased risk of in-hospital mortality. In contrast, older age, male, ICU admission, and the presence of an indwelling urinary catheter were significantly associated with an increased risk of mortality for patients with CRKP. Conclusions: Both CRAB and CRKP lead to high rates of mortality. The MLST profile showed that the genomic patterns of CRKP were highly diverse, whereas CRAB strains had low genetic diversity. To tackle these challenging pathogens, robust surveillance and an in-depth understanding of molecular epidemiology and genomics studies are needed to tailor infection control strategies and individualise treatment approaches.
dc.description.confidentialfalse
dc.edition.editionNovember 2024
dc.format.pagination1107-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/39596800
dc.identifier.citationLau MY, Ponnampalavanar S, Chong CW, Dwiyanto J, Lee YQ, Woon JJ, Kong ZX, Jasni AS, Lee MCC, Obaidellah UH, Teh CSJ. (2024). The Characterisation of Carbapenem-Resistant Acinetobacter baumannii and Klebsiella pneumoniae in a Teaching Hospital in Malaysia.. Antibiotics (Basel). 13. 11. (pp. 1107-).
dc.identifier.doi10.3390/antibiotics13111107
dc.identifier.eissn2079-6382
dc.identifier.elements-typejournal-article
dc.identifier.issn2079-6382
dc.identifier.number1107
dc.identifier.piiantibiotics13111107
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/72293
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2079-6382/13/11/1107
dc.relation.isPartOfAntibiotics (Basel)
dc.rights(c) 2024 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAcinetobacter baumannii
dc.subjectKlebsiella pneumoniae
dc.subjectantimicrobial-resistant
dc.subjectcarbapenem-resistant organisms
dc.subjectepidemiology
dc.titleThe Characterisation of Carbapenem-Resistant Acinetobacter baumannii and Klebsiella pneumoniae in a Teaching Hospital in Malaysia.
dc.typeJournal article
pubs.elements-id492595
pubs.organisational-groupOther
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
492595 PDF.pdf
Size:
1.64 MB
Format:
Adobe Portable Document Format
Description:
Published version.pdf
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
9.22 KB
Format:
Plain Text
Description:
Download
Collections
Journal Articles