Hepatotoxicity of titanium dioxide nanoparticles.

Simple item page
dc.citation.volumeEarly View
dc.contributor.authorKhan J
dc.contributor.authorKim ND
dc.contributor.authorBromhead C
dc.contributor.authorTruman P
dc.contributor.authorKruger MC
dc.contributor.authorMallard BL
dc.coverage.spatialEngland
dc.date.accessioned2024-06-13T02:38:28Z
dc.date.available2024-06-13T02:38:28Z
dc.date.issued2024-05-13
dc.description.abstractThe food additive E171 (titanium dioxide, TiO2), is widely used in foods, pharmaceuticals and cosmetics. It is a fine white powder, with at least one third of its particles sized in the nanoparticulate (˂100 nm range, TiO2 NPs). The use of E171 is controversial as its relevant risk assessment has never been satisfactorily accomplished. In vitro and in vivo studies have shown dose-dependent toxicity in various organs including the liver. TiO2 NPs have been shown to induce inflammation, cell death and structural and functional changes within the liver. The toxicity of TiO2 NPs in experimental models varies between organs and according to their physiochemical characteristics and parameters such as dosage and route of administration. Among these factors, ingestion is the most significant exposure route, and the liver is a key target organ. The aim of this review is to highlight the reported adverse effects of orally administered TiO2 NPs on the liver and to discuss the controversial state of its toxicity.
dc.description.confidentialfalse
dc.format.pagination1-24
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/38740968
dc.identifier.citationKhan J, Kim ND, Bromhead C, Truman P, Kruger MC, Mallard BL. (2024). Hepatotoxicity of titanium dioxide nanoparticles.. J Appl Toxicol. Early View. (pp. 1-24).
dc.identifier.doi10.1002/jat.4626
dc.identifier.eissn1099-1263
dc.identifier.elements-typejournal-article
dc.identifier.issn0260-437X
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/69836
dc.languageeng
dc.publisherJohn Wiley & Sons Ltd
dc.publisher.urihttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jat.4626
dc.relation.isPartOfJ Appl Toxicol
dc.rights(c) 2024 The Author/s
dc.rightsCC BY-NC 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectE171
dc.subjectliver
dc.subjectnanoparticles
dc.subjectoxidative stress
dc.subjecttitanium dioxide
dc.titleHepatotoxicity of titanium dioxide nanoparticles.
dc.typeJournal article
pubs.elements-id488920
pubs.organisational-groupCollege of Health
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