Ankyrin2 is essential for neuronal morphogenesis and long-term courtship memory in Drosophila

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dc.citation.issue1
dc.citation.volume16
dc.contributor.authorSchwartz S
dc.contributor.authorWilson SJ
dc.contributor.authorHale TK
dc.contributor.authorFitzsimons HL
dc.date.accessioned2023-12-15T01:22:40Z
dc.date.accessioned2024-07-25T06:33:48Z
dc.date.available2021-07-18
dc.date.available2023-12-15T01:22:40Z
dc.date.available2024-07-25T06:33:48Z
dc.date.issued2023-05-16
dc.description.abstractDysregulation of HDAC4 expression and/or nucleocytoplasmic shuttling results in impaired neuronal morphogenesis and long-term memory in Drosophila melanogaster. A recent genetic screen for genes that interact in the same molecular pathway as HDAC4 identified the cytoskeletal adapter Ankyrin2 (Ank2). Here we sought to investigate the role of Ank2 in neuronal morphogenesis, learning and memory. We found that Ank2 is expressed widely throughout the Drosophila brain where it localizes predominantly to axon tracts. Pan-neuronal knockdown of Ank2 in the mushroom body, a region critical for memory formation, resulted in defects in axon morphogenesis. Similarly, reduction of Ank2 in lobular plate tangential neurons of the optic lobe disrupted dendritic branching and arborization. Conditional knockdown of Ank2 in the mushroom body of adult Drosophila significantly impaired long-term memory (LTM) of courtship suppression, and its expression was essential in the γ neurons of the mushroom body for normal LTM. In summary, we provide the first characterization of the expression pattern of Ank2 in the adult Drosophila brain and demonstrate that Ank2 is critical for morphogenesis of the mushroom body and for the molecular processes required in the adult brain for the formation of long-term memories.
dc.description.confidentialfalse
dc.edition.editionDecember 2023
dc.identifier.citationSchwartz S, Wilson S, Hale T, Fitzsimons H. (2021). Ankyrin2 is required for neuronal morphogenesis and long-term memory and interacts genetically with HDAC4. Molecular Brain. 16. 1.
dc.identifier.doi10.1101/2021.07.18.452850
dc.identifier.elements-typejournal-article
dc.identifier.issn1756-6606
dc.identifier.number42
dc.identifier.piis13041-023-01026-w
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70426
dc.languageEnglish
dc.publisherBioMed Central Ltd
dc.publisher.urihttps://molecularbrain.biomedcentral.com/articles/10.1186/s13041-023-01026-w
dc.relation.isPartOfMolecular Brain
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAnkyrin repeat
dc.subjectAnkyrin2
dc.subjectANK3
dc.subjectHistone deacetylase
dc.subjectHDAC4
dc.subjectMemory
dc.subjectNeuron
dc.subjectDrosophila
dc.subjectMushroom body
dc.titleAnkyrin2 is essential for neuronal morphogenesis and long-term courtship memory in Drosophila
dc.typeJournal article
pubs.elements-id454374
pubs.organisational-groupOther
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