Cerebral autoregulation across the menstrual cycle in eumenorrheic women

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dc.citation.issue9
dc.citation.volume10
dc.contributor.authorKorad S
dc.contributor.authorMündel T
dc.contributor.authorFan J-L
dc.contributor.authorPerry BG
dc.coverage.spatialUnited States
dc.date.accessioned2023-07-25T21:24:22Z
dc.date.accessioned2023-09-04T01:40:55Z
dc.date.available2022-05-06
dc.date.available2023-07-25T21:24:22Z
dc.date.available2023-09-04T01:40:55Z
dc.date.issued2022-05-06
dc.date.updated2023-07-25T00:03:07Z
dc.descriptionThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.description.abstractThere is emerging evidence that ovarian hormones play a significant role in the lower stroke incidence observed in pre-menopausal women compared with men. However, the role of ovarian hormones in cerebrovascular regulation remains to be elucidated. We examined the blood pressure-cerebral blood flow relationship (cerebral autoregulation) across the menstrual cycle in eumenorrheic women (n = 12; mean ± SD: age, 31 ± 7 years). Participants completed sit-to-stand and Valsalva maneuvers (VM, mouth pressure of 40 mmHg for 15 s) during the early follicular (EF), late follicular (LF), and mid-luteal (ML) menstrual cycle phases, confirmed by serum measurement of progesterone and 17β-estradiol. Middle cerebral artery blood velocity (MCAv), arterial blood pressure and partial pressure of end-tidal carbon dioxide were measured. Cerebral autoregulation was assessed by transfer function analysis during spontaneous blood pressure oscillations, rate of regulation (RoR) during sit-to-stand maneuvers, and Tieck's autoregulatory index during VM phases II and IV (AI-II and AI-IV, respectively). Resting mean MCAv (MCAvmean ), blood pressure, and cerebral autoregulation were unchanged across the menstrual cycle (all p > 0.12). RoR tended to be different (EF, 0.25 ± 0.06; LF; 0.19 ± 0.04; ML, 0.18 ± 0.12 sec-1 ; p = 0.07) and demonstrated a negative relationship with 17β-estradiol (R2  = 0.26, p = 0.02). No changes in AI-II (EF, 1.95 ± 1.20; LF, 1.67 ± 0.77 and ML, 1.20 ± 0.55) or AI-IV (EF, 1.35 ± 0.21; LF, 1.27 ± 0.26 and ML, 1.20 ± 0.2) were observed (p = 0.25 and 0.37, respectively). Although, a significant interaction effect (p = 0.02) was observed for the VM MCAvmean response. These data indicate that the menstrual cycle has limited impact on cerebrovascular autoregulation, but individual differences should be considered.
dc.description.confidentialfalse
dc.edition.editionMay 2022
dc.format.extente15287-
dc.identifiere15287
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/35524340
dc.identifier.citationKorad S, Mündel T, Fan J-L, Perry BG. (2022). Cerebral autoregulation across the menstrual cycle in eumenorrheic women.. Physiol Rep. 10. 9. (pp. e15287-).
dc.identifier.doi10.14814/phy2.15287
dc.identifier.eissn2051-817X
dc.identifier.elements-typejournal-article
dc.identifier.harvestedMassey_Dark
dc.identifier.issn2051-817X
dc.identifier.urihttp://hdl.handle.net/10179/19896
dc.languageeng
dc.publisherWiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society
dc.publisher.urihttps://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.15287
dc.relation.isPartOfPhysiol Rep
dc.rights(c) The author/s CC BYen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectcerebral autoregulation
dc.subjecteumenorrheic women
dc.subjectmenstrual cycle
dc.subjectAdult
dc.subjectCerebrovascular Circulation
dc.subjectEstradiol
dc.subjectFemale
dc.subjectHomeostasis
dc.subjectHumans
dc.subjectMale
dc.subjectMenstrual Cycle
dc.subjectMiddle Cerebral Artery
dc.subjectYoung Adult
dc.titleCerebral autoregulation across the menstrual cycle in eumenorrheic women
dc.typeJournal article
pubs.elements-id453272
pubs.organisational-groupOther
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