Characterisation of the Plasma and Faecal Metabolomes in Participants with Functional Gastrointestinal Disorders.

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dc.citation.issue24
dc.citation.volume25
dc.contributor.authorFraser K
dc.contributor.authorJames SC
dc.contributor.authorYoung W
dc.contributor.authorGearry RB
dc.contributor.authorHeenan PE
dc.contributor.authorKeenan JI
dc.contributor.authorTalley NJ
dc.contributor.authorMcNabb WC
dc.contributor.authorRoy NC
dc.contributor.editorFukui H
dc.coverage.spatialSwitzerland
dc.date.accessioned2025-01-15T22:18:03Z
dc.date.available2025-01-15T22:18:03Z
dc.date.issued2024-12-16
dc.description.abstractThere is evidence of perturbed microbial and host processes in the gastrointestinal tract of individuals with functional gastrointestinal disorders (FGID) compared to healthy controls. The faecal metabolome provides insight into the metabolic processes localised to the intestinal tract, while the plasma metabolome highlights the overall perturbances of host and/or microbial responses. This study profiled the faecal (n = 221) and plasma (n = 206) metabolomes of individuals with functional constipation (FC), constipation-predominant irritable bowel syndrome (IBS-C), functional diarrhoea (FD), diarrhoea-predominant IBS (IBS-D) and healthy controls (identified using the Rome Criteria IV) using multimodal LC-MS technologies. Discriminant analysis separated patients with the 'all constipation' group (FC and IBS-C) from the healthy control group and 'all diarrhoea' group (FD and IBS-D) from the healthy control group in both sample types. In plasma, almost all multimodal metabolite analyses separated the 'all constipation' or 'all diarrhoea' group from the healthy controls, and the IBS-C or IBS-D group from the healthy control group. Plasma phospholipids and metabolites linked to several amino acid and nucleoside pathways differed (p < 0.05) between healthy controls and IBS-C. In contrast, metabolites involved in bile acid and amino acid metabolism were the key differentiating classes in the plasma of subjects with IBS-D from healthy controls. Faecal lipids, particularly ceramides, diglycerides, and triglycerides, varied (p < 0.05) between healthy controls and the 'all constipation' group and between healthy controls and 'all diarrhoea' group. The faecal and plasma metabolomes showed perturbations between constipation, diarrhoea and healthy control groups that may reflect processes and mechanisms linked to FGIDs.
dc.description.confidentialfalse
dc.edition.editionDecember-2 2024
dc.format.pagination13465-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/39769229
dc.identifier.citationFraser K, James SC, Young W, Gearry RB, Heenan PE, Keenan JI, Talley NJ, McNabb WC, Roy NC. (2024). Characterisation of the Plasma and Faecal Metabolomes in Participants with Functional Gastrointestinal Disorders.. Int J Mol Sci. 25. 24. (pp. 13465-).
dc.identifier.doi10.3390/ijms252413465
dc.identifier.eissn1422-0067
dc.identifier.elements-typejournal-article
dc.identifier.issn1422-0067
dc.identifier.number13465
dc.identifier.piiijms252413465
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/72377
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttp://mdpi.com/1422-0067/25/24/13465
dc.relation.isPartOfInt J Mol Sci
dc.rights(c) The author/sen
dc.rights.licenseCC BYen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectLC-MS
dc.subjectbiomarkers
dc.subjectconstipation
dc.subjectdiarrhoea
dc.subjectgut-brain
dc.subjectmetabolomics
dc.subjectHumans
dc.subjectFeces
dc.subjectMale
dc.subjectFemale
dc.subjectMetabolome
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectGastrointestinal Diseases
dc.subjectConstipation
dc.subjectIrritable Bowel Syndrome
dc.subjectDiarrhea
dc.subjectMetabolomics
dc.subjectCase-Control Studies
dc.titleCharacterisation of the Plasma and Faecal Metabolomes in Participants with Functional Gastrointestinal Disorders.
dc.typeJournal article
pubs.elements-id493314
pubs.organisational-groupOther
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