Does chronic oral contraceptive use detrimentally affect C-reactive protein or iron status for endurance-trained women?
dc.citation.issue | 14 | |
dc.citation.volume | 11 | |
dc.contributor.author | Badenhorst CE | |
dc.contributor.author | Govus AD | |
dc.contributor.author | Mündel T | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2024-06-19T20:43:34Z | |
dc.date.available | 2024-06-19T20:43:34Z | |
dc.date.issued | 2023-07-24 | |
dc.description.abstract | PURPOSE: Chronic use of the oral contraceptive pill (OCP) is reported to increase C-reactive protein (CRP) levels and increase the risk of cardiovascular disease in premenopausal females. METHODS: A secondary analysis of data from two research studies in eumenorrheic (n = 8) and OCP (n = 8) female athletes. Basal CRP and iron parameters were included in the analysis. Sample collection occurred following a standardized exercise and nutritional control for 24 h. Eumenorrheic females were tested in the early-follicular and mid-luteal phases, and the OCP users were tested in quasi-follicular and quasi-luteal phases (both active pill periods). RESULTS: A main effect for group (p < 0.01) indicated that average CRP concentration was higher in OCP users compared with eumenorrheic females, regardless of the day of measurement within the cycle. Results demonstrate a degree of iron parameters moderation throughout the menstrual cycle that is influenced by basal CRP levels; however, no linear relationship with CRP, serum iron, and ferritin was observed. CONCLUSIONS: Basal CRP values were consistently higher in the OCP group despite participants being in a rested state. These results may indicate a potential risk of cardiovascular disease in prolonged users of the OCP when compared to eumenorrheic female athletes. | |
dc.description.confidential | false | |
dc.edition.edition | Jul 2023 | |
dc.format.pagination | e15777- | |
dc.identifier.author-url | https://www.ncbi.nlm.nih.gov/pubmed/37487629 | |
dc.identifier.citation | Badenhorst CE, Govus AD, Mündel T. (2023). Does chronic oral contraceptive use detrimentally affect C-reactive protein or iron status for endurance-trained women?. Physiol Rep. 11. 14. (pp. e15777-). | |
dc.identifier.doi | 10.14814/phy2.15777 | |
dc.identifier.eissn | 2051-817X | |
dc.identifier.elements-type | journal-article | |
dc.identifier.issn | 2051-817X | |
dc.identifier.number | e15777 | |
dc.identifier.uri | https://mro.massey.ac.nz/handle/10179/69925 | |
dc.language | eng | |
dc.publisher | Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. | |
dc.publisher.uri | https://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.15777 | |
dc.relation.isPartOf | Physiol Rep | |
dc.rights | (c) 2023 The Author/s | |
dc.rights | CC BY 4.0 | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | cardiovascular risk | |
dc.subject | exercise | |
dc.subject | females | |
dc.subject | inflammation | |
dc.subject | ovarian hormones | |
dc.subject | Humans | |
dc.subject | Female | |
dc.subject | Iron | |
dc.subject | C-Reactive Protein | |
dc.subject | Cardiovascular Diseases | |
dc.subject | Ferritins | |
dc.subject | Contraceptives, Oral | |
dc.title | Does chronic oral contraceptive use detrimentally affect C-reactive protein or iron status for endurance-trained women? | |
dc.type | Journal article | |
pubs.elements-id | 479163 | |
pubs.organisational-group | College of Health |