Bioactive Yoghurt Containing Curcumin and Chlorogenic Acid Reduces Inflammation in Postmenopausal Women

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dc.citation.issue21
dc.citation.volume14
dc.contributor.authorAhmed Nasef N
dc.contributor.authorThota RN
dc.contributor.authorMutukumira AN
dc.contributor.authorRutherfurd-Markwick K
dc.contributor.authorDickens M
dc.contributor.authorGopal P
dc.contributor.authorSingh H
dc.contributor.authorGarg ML
dc.contributor.editorBordoni A
dc.coverage.spatialSwitzerland
dc.date.accessioned2023-07-11T03:08:28Z
dc.date.accessioned2023-09-04T01:40:39Z
dc.date.available2022-11-02
dc.date.available2023-07-11T03:08:28Z
dc.date.available2023-09-04T01:40:39Z
dc.date.issued2022-11-02
dc.date.updated2023-07-10T03:47:09Z
dc.descriptionCopyright: © 2022 by the authors.
dc.description.abstractMenopause is marked by a gradual and permanent decrease of estrogen from the ovaries, leading to metabolic and physiological changes in the body. Combined with increased body mass index, postmenopausal women have elevated systemic inflammation and metabolic disturbances leading to increased risk of developing chronic diseases. A bioactive coconut yoghurt containing curcumin and chlorogenic acid was developed with the potential to target inflammatory processes. In this randomized crossover study, healthy postmenopausal women with a BMI of 25-40 were recruited to consume 125 g of either the bioactive or placebo yoghurt. Blood samples were collected at baseline, 30 min, and 1, 2, 3 and 4 h postprandially. Plasma inflammatory markers (TNFα and IL6) and metabolic markers (triglycerides, insulin and glucose) were measured. Participants had significantly lower plasma TNFα Cmax after consumption of the bioactive yoghurt compared to placebo (mean difference = 0.3 pg/mL; p = 0.04). Additionally, plasma TNFα was significantly lower postprandially compared to baseline after consumption of the bioactive yogurt but not the placebo. No differences were observed in the metabolic markers measured. Conclusions: The bioactive yoghurt fortified with curcumin and chlorogenic acid has the potential to reduce inflammatory mediators; however, a larger and longer-term study is required to confirm these findings.
dc.description.confidentialfalse
dc.format.extent4619-
dc.identifier4619
dc.identifiernu14214619
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/36364884
dc.identifier.citationAhmed Nasef N, Thota RN, Mutukumira AN, Rutherfurd-Markwick K, Dickens M, Gopal P, Singh H, Garg ML. (2022). Bioactive Yoghurt Containing Curcumin and Chlorogenic Acid Reduces Inflammation in Postmenopausal Women.. Nutrients. 14. 21. (pp. 4619-).
dc.identifier.doi10.3390/nu14214619
dc.identifier.eissn2072-6643
dc.identifier.elements-typejournal-article
dc.identifier.harvestedMassey_Dark
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/10179/19860
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2072-6643/14/21/4619
dc.relation.isPartOfNutrients
dc.rightsCC BY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectchlorogenic acid
dc.subjectcurcumin
dc.subjectfunctional food
dc.subjectinflammation
dc.subjectmenopause
dc.subjectyoghurt
dc.subjectHumans
dc.subjectFemale
dc.subjectYogurt
dc.subjectCurcumin
dc.subjectTumor Necrosis Factor-alpha
dc.subjectChlorogenic Acid
dc.subjectPostmenopause
dc.subjectCross-Over Studies
dc.subjectInflammation
dc.titleBioactive Yoghurt Containing Curcumin and Chlorogenic Acid Reduces Inflammation in Postmenopausal Women
dc.typeJournal article
pubs.elements-id457912
pubs.organisational-groupOther
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