Potential modulatory mechanisms of action by long-chain polyunsaturated fatty acids on bone cell and chondrocyte metabolism

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dc.citation.volume83
dc.contributor.authorAbshirini M
dc.contributor.authorIlesanmi-Oyelere BL
dc.contributor.authorKruger MC
dc.coverage.spatialEngland
dc.date.accessioned2023-07-12T02:06:33Z
dc.date.accessioned2023-09-04T01:40:41Z
dc.date.available2021-07-02
dc.date.available2023-07-12T02:06:33Z
dc.date.available2023-09-04T01:40:41Z
dc.date.issued2021-07-03
dc.date.updated2023-07-11T04:12:27Z
dc.description(c) 2021 The Author/s
dc.description.abstractLong-chain polyunsaturated fatty acids (LCPUFAs) and their metabolites are considered essential factors to support bone and joint health. The n-6 PUFAs suppress the osteoblasts differentiation via increasing peroxisome proliferator-activated receptor gamma (PPARγ) expression and promoting adipogenesis while n-3 PUFAs promote osteoblastogenesis by down-regulating PPARγ and enhancing osteoblastic activity. Arachidonic acid (AA) and its metabolite prostaglandin E2 (PGE2) are key regulators of osteoclast differentiation via induction of the receptor activator of nuclear factor kappa-Β ligand (RANKL) pathway. Marine-derived n-3 LCPUFAs have been shown to inhibit osteoclastogenesis by decreasing the osteoprotegerin (OPG)/RANKL signalling pathway mediated by a reduction of pro-inflammatory PGE2 derived from AA. Omega-3 PUFAs reduce the expression of cartilage degrading enzyme matrix metalloproteinase-13 (MMP-13) and a disintegrin and metalloprotease with thrombospondin motifs-5 (ADAMTS-5) protein, oxidative stress and thereby apoptosis via nuclear factor kappa-betta (NF-kβ) and inducible nitric oxide synthase (iNOS) pathways. In this review, a diverse range of important effects of LCPUFAs on bone cells and chondrocyte was highlighted through different mechanisms of action established by cell cultures and animal studies. This review allows a better understanding of the possible role of LCPUFAs in bone and chondrocyte metabolism as potential therapeutics in combating the pathological complications such as osteoporosis and osteoarthritis.
dc.description.confidentialfalse
dc.edition.editionJuly 2021
dc.format.extent101113-
dc.identifierARTN 101113
dc.identifierS0163-7827(21)00029-1
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/34217732
dc.identifier.citationAbshirini M, Ilesanmi-Oyelere BL, Kruger MC. (2021). Potential modulatory mechanisms of action by long-chain polyunsaturated fatty acids on bone cell and chondrocyte metabolism.. Prog Lipid Res. 83. (pp. 101113-).
dc.identifier.doi10.1016/j.plipres.2021.101113
dc.identifier.eissn1873-2194
dc.identifier.elements-typejournal-article
dc.identifier.harvestedMassey_Dark
dc.identifier.issn0163-7827
dc.identifier.urihttp://hdl.handle.net/10179/19866
dc.languageeng
dc.publisherElsevier Ltd
dc.publisher.urihttps://www.sciencedirect.com/science/article/pii/S0163782721000291
dc.relation.isPartOfProg Lipid Res
dc.rightsCC BY-NC-ND 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectChondrocytes
dc.subjectLong-chain polyunsaturated fatty acids
dc.subjectOsteoblasts
dc.subjectOsteoclasts
dc.subjectPPAR ligands
dc.subjectProstaglandins
dc.subjectAnimals
dc.subjectCell Differentiation
dc.subjectChondrocytes
dc.subjectFatty Acids
dc.subjectFatty Acids, Omega-3
dc.subjectFatty Acids, Unsaturated
dc.subjectNF-kappa B
dc.titlePotential modulatory mechanisms of action by long-chain polyunsaturated fatty acids on bone cell and chondrocyte metabolism
dc.typeJournal article
pubs.elements-id447134
pubs.organisational-groupOther
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