Vitamin B and One-Carbon Metabolite Profiles Show Divergent Associations with Cardiometabolic Risk Markers but not Cognitive Function in Older New Zealand Adults: A Secondary Analysis of the REACH Study.

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dc.citation.issue12
dc.citation.volume153
dc.contributor.authorGillies NA
dc.contributor.authorMilan AM
dc.contributor.authorCameron-Smith D
dc.contributor.authorMumme KD
dc.contributor.authorConlon CA
dc.contributor.authorvon Hurst PR
dc.contributor.authorHaskell-Ramsay CF
dc.contributor.authorJones B
dc.contributor.authorRoy NC
dc.contributor.authorCoad J
dc.contributor.authorWall CR
dc.contributor.authorBeck KL
dc.coverage.spatialUnited States
dc.date.accessioned2024-06-19T02:31:31Z
dc.date.available2024-06-19T02:31:31Z
dc.date.issued2023-12-07
dc.description.abstractBACKGROUND: Vitamin B inadequacies and elevated homocysteine status have been associated with impaired cognitive and cardiometabolic health with aging. There is, however, a scarcity of research investigating integrated profiles of one-carbon (1C) metabolites in this context, including metabolites of interconnected folate, methionine, choline oxidation, and transsulfuration pathways. OBJECTIVES: The study aimed to examine associations between vitamins B and 1C metabolites with cardiometabolic health and cognitive function in healthy older adults, including the interactive effects of Apolipoprotein E-ε4 status. METHODS: Three hundred and thirteen healthy participants (65-74 y, 65% female) were analyzed. Vitamins B were estimated according to dietary intake (4-d food records) and biochemical status (serum folate and vitamin B12). Fasting plasma 1C metabolites were quantified by liquid chromatography with tandem mass spectrometry. Measures of cardiometabolic health included biochemical (lipid panel, blood glucose) and anthropometric markers. Cognitive function was assessed by the Computerized Mental Performance Assessment System (COMPASS) and Montreal Cognitive Assessment (MoCA). Associations were analyzed using multivariate linear (COMPASS, cardiometabolic health) and Poisson (MoCA) regression modeling. RESULTS: Over 90% of participants met dietary recommendations for riboflavin and vitamins B6 and B12, but only 78% of males and 67% of females achieved adequate folate intakes. Higher serum folate and plasma betaine and glycine concentrations were associated with favorable cardiometabolic markers, whereas higher plasma choline and homocysteine concentrations were associated with greater cardiometabolic risk based on body mass index and serum lipids concentration values (P< 0.05). Vitamins B and homocysteine were not associated with cognitive performance in this cohort, though higher glycine concentrations were associated with better global cognitive performance (P = 0.017), episodic memory (P = 0.016), and spatial memory (P = 0.027) scores. Apolipoprotein E-ε4 status did not modify the relationship between vitamins B or 1C metabolites with cognitive function in linear regression analyses. CONCLUSIONS: Vitamin B and 1C metabolite profiles showed divergent associations with cardiometabolic risk markers and limited associations with cognitive performance in this cohort of healthy older adults.
dc.description.confidentialfalse
dc.edition.editionDecember 2023
dc.format.pagination3529-3542
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37863266
dc.identifier.citationGillies NA, Milan AM, Cameron-Smith D, Mumme KD, Conlon CA, von Hurst PR, Haskell-Ramsay CF, Jones B, Roy NC, Coad J, Wall CR, Beck KL. (2023). Vitamin B and One-Carbon Metabolite Profiles Show Divergent Associations with Cardiometabolic Risk Markers but not Cognitive Function in Older New Zealand Adults: A Secondary Analysis of the REACH Study.. J Nutr. 153. 12. (pp. 3529-3542).
dc.identifier.doi10.1016/j.tjnut.2023.10.012
dc.identifier.eissn1541-6100
dc.identifier.elements-typejournal-article
dc.identifier.issn0022-3166
dc.identifier.piiS0022-3166(23)72666-7
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/69910
dc.languageeng
dc.publisherElsevier B.V.
dc.publisher.urihttps://www.sciencedirect.com/science/article/pii/S0022316623726667
dc.relation.isPartOfJ Nutr
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectOne-carbon metabolites
dc.subjectcholine
dc.subjectcognition
dc.subjectglycine
dc.subjecthomocysteine
dc.subjectmetabolic health
dc.subjectolder adults
dc.subjectvitamins B
dc.subjectMale
dc.subjectHumans
dc.subjectFemale
dc.subjectAged
dc.subjectNew Zealand
dc.subjectVitamin B Complex
dc.subjectFolic Acid
dc.subjectVitamin B 12
dc.subjectCognition
dc.subjectCholine
dc.subjectCardiovascular Diseases
dc.subjectGlycine
dc.subjectHomocysteine
dc.subjectApolipoproteins
dc.titleVitamin B and One-Carbon Metabolite Profiles Show Divergent Associations with Cardiometabolic Risk Markers but not Cognitive Function in Older New Zealand Adults: A Secondary Analysis of the REACH Study.
dc.typeJournal article
pubs.elements-id481018
pubs.organisational-groupCollege of Health
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