Parity and the risk of incident dementia: a COSMIC study

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dc.citation.volume29
dc.contributor.authorBae JB
dc.contributor.authorLipnicki DM
dc.contributor.authorHan JW
dc.contributor.authorSachdev PS
dc.contributor.authorKim TH
dc.contributor.authorKwak KP
dc.contributor.authorKim BJ
dc.contributor.authorKim SG
dc.contributor.authorKim JL
dc.contributor.authorMoon SW
dc.contributor.authorPark JH
dc.contributor.authorRyu S-H
dc.contributor.authorYoun JC
dc.contributor.authorLee DY
dc.contributor.authorLee DW
dc.contributor.authorLee SB
dc.contributor.authorLee JJ
dc.contributor.authorJhoo JH
dc.contributor.authorSkoog I
dc.contributor.authorNajar J
dc.contributor.authorSterner TR
dc.contributor.authorScarmeas N
dc.contributor.authorYannakoulia M
dc.contributor.authorDardiotis E
dc.contributor.authorRiedel-Heller S
dc.contributor.authorRoehr S
dc.contributor.authorPabst A
dc.contributor.authorDing D
dc.contributor.authorZhao Q
dc.contributor.authorLiang X
dc.contributor.authorLobo A
dc.contributor.authorDe-la-Cámara C
dc.contributor.authorLobo E
dc.contributor.authorKim KW
dc.contributor.authorfor Cohort Studies of Memory in an International Consortium (COSMIC)
dc.coverage.spatialEngland
dc.date.accessioned2023-11-24T00:25:05Z
dc.date.accessioned2024-07-25T06:33:52Z
dc.date.available2020-10-20
dc.date.available2023-11-24T00:25:05Z
dc.date.available2024-07-25T06:33:52Z
dc.date.issued2020-10-20
dc.description.abstractAims To investigate the association between parity and the risk of incident dementia in women. Methods We pooled baseline and follow-up data for community-dwelling women aged 60 or older from six population-based, prospective cohort studies from four European and two Asian countries. We investigated the association between parity and incident dementia using Cox proportional hazards regression models adjusted for age, educational level, hypertension, diabetes mellitus and cohort, with additional analysis by dementia subtype (Alzheimer dementia (AD) and non-Alzheimer dementia (NAD)). Results Of 9756 women dementia-free at baseline, 7010 completed one or more follow-up assessments. The mean follow-up duration was 5.4 ± 3.1 years and dementia developed in 550 participants. The number of parities was associated with the risk of incident dementia (hazard ratio (HR) = 1.07, 95% confidence interval (CI) = 1.02–1.13). Grand multiparity (five or more parities) increased the risk of dementia by 30% compared to 1–4 parities (HR = 1.30, 95% CI = 1.02–1.67). The risk of NAD increased by 12% for every parity (HR = 1.12, 95% CI = 1.02–1.23) and by 60% for grand multiparity (HR = 1.60, 95% CI = 1.00–2.55), but the risk of AD was not significantly associated with parity. Conclusions Grand multiparity is a significant risk factor for dementia in women. This may have particularly important implications for women in low and middle-income countries where the fertility rate and prevalence of grand multiparity are high.
dc.format.paginatione176-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/33077022
dc.identifier.citationBae JB, Lipnicki DM, Han JW, Sachdev PS, Kim TH, Kwak KP, Kim BJ, Kim SG, Kim JL, Moon SW, Park JH, Ryu S-H, Youn JC, Lee DY, Lee DW, Lee SB, Lee JJ, Jhoo JH, Skoog I, Najar J, Sterner TR, Scarmeas N, Yannakoulia M, Dardiotis E, Riedel-Heller S, Roehr S, Pabst A, Ding D, Zhao Q, Liang X, Lobo A, De-la-Cámara C, Lobo E, Kim KW, for Cohort Studies of Memory in an International Consortium (COSMIC) . (2020). Parity and the risk of incident dementia: a COSMIC study.. Epidemiol Psychiatr Sci. 29. (pp. e176-).
dc.identifier.doi10.1017/S2045796020000876
dc.identifier.eissn2045-7979
dc.identifier.elements-typejournal-article
dc.identifier.issn2045-7960
dc.identifier.piiS2045796020000876
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70432
dc.languageeng
dc.publisherCambridge University Press
dc.relation.isPartOfEpidemiol Psychiatr Sci
dc.rights(c) 2020 The Author/s
dc.rightsCC BY-NC-SA 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectDementia
dc.subjectgeriatric psychiatry
dc.subjectrisk factors
dc.subjectwomen
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAlzheimer Disease
dc.subjectChina
dc.subjectCohort Studies
dc.subjectDementia
dc.subjectEurope
dc.subjectFemale
dc.subjectGeriatric Psychiatry
dc.subjectHumans
dc.subjectIncidence
dc.subjectIndependent Living
dc.subjectMiddle Aged
dc.subjectParity
dc.subjectPregnancy
dc.subjectProportional Hazards Models
dc.subjectRepublic of Korea
dc.subjectRisk Factors
dc.subjectSocioeconomic Factors
dc.titleParity and the risk of incident dementia: a COSMIC study
dc.typeJournal article
pubs.elements-id455003
pubs.organisational-groupOther
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