Astragalosides Supplementation Enhances Intrinsic Muscle Repair Capacity Following Eccentric Exercise-Induced Injury

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dc.citation.issue20
dc.citation.volume14
dc.contributor.authorYeh T-S
dc.contributor.authorLei T-H
dc.contributor.authorBarnes MJ
dc.contributor.authorZhang L
dc.coverage.spatialSwitzerland
dc.date.accessioned2023-08-17T23:57:47Z
dc.date.accessioned2023-09-04T01:41:28Z
dc.date.available2022-10-17
dc.date.available2023-08-17T23:57:47Z
dc.date.available2023-09-04T01:41:28Z
dc.date.issued2022-10
dc.date.updated2023-08-17T23:48:50Z
dc.descriptionCopyright: © 2022 by the authors.en_US
dc.description.abstractAstragalosides have been shown to enhance endurance exercise capacity in vivo and promote muscular hypertrophy in vitro. However, it remains unknown whether astragalosides supplementation can alter inflammatory response and enhance muscle recovery after damage in humans. We therefore aimed to evaluate the effect of astragalosides supplementation on muscle's intrinsic capacity to regenerate and repair itself after exercise-induced damage. Using a randomized double-blind placebo-controlled cross-over design, eleven male participants underwent 7 days of astragalosides supplementation (in total containing 4 mg of astragalosides per day) or a placebo control, following an eccentric exercise protocol. Serum blood samples and variables related to muscle function were collected prior to and immediately following the muscle damage protocol and also at 2 h, and 1, 2, 3, 5, and 7 days of the recovery period, to assess the pro-inflammatory cytokine response, the secretion of muscle regenerative factors, and muscular strength. Astragalosides supplementation reduced biomarkers of skeletal muscle damage (serum CK, LDH, and Mb), when compared to the placebo, at 1, 2, and 3 days following the muscle damage protocol. Astragalosides supplementation suppressed the secretion of IL-6 and TNF-α, whilst increasing the release of IGF-1 during the initial stages of muscle recovery. Furthermore, following astragaloside supplementation, muscular strength returned to baseline 2 days earlier than the placebo. Astragalosides supplementation shortens the duration of inflammation, enhances the regeneration process and restores muscle strength following eccentric exercise-induced injury.
dc.format.extent4339-
dc.identifiernu14204339
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/36297022
dc.identifier.citationYeh T-S, Lei T-H, Barnes MJ, Zhang L. (2022). Astragalosides Supplementation Enhances Intrinsic Muscle Repair Capacity Following Eccentric Exercise-Induced Injury.. Nutrients. 14. 20. (pp. 4339-).
dc.identifier.doi10.3390/nu14204339
dc.identifier.eissn2072-6643
dc.identifier.elements-typejournal-article
dc.identifier.harvestedMassey_Dark
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/10179/19973
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.relation.isPartOfNutrients
dc.rightsCC BYen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectastragalus
dc.subjectdelayed-onset muscle soreness
dc.subjectinflammatory
dc.subjectmuscle damage
dc.subjectmuscle regeneration
dc.subjectmuscular strength
dc.subjecttraditional Chinese medicine
dc.subjectHumans
dc.subjectMale
dc.subjectBiomarkers
dc.subjectCytokines
dc.subjectDietary Supplements
dc.subjectDouble-Blind Method
dc.subjectInsulin-Like Growth Factor I
dc.subjectInterleukin-6
dc.subjectMuscle, Skeletal
dc.subjectMyalgia
dc.subjectTumor Necrosis Factor-alpha
dc.subjectExercise
dc.subjectTriterpenes
dc.subjectSaponins
dc.subjectCross-Over Studies
dc.titleAstragalosides Supplementation Enhances Intrinsic Muscle Repair Capacity Following Eccentric Exercise-Induced Injury
dc.typeJournal article
pubs.elements-id457752
pubs.organisational-groupOther
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