An Investigation about Gene Modules Associated with hDPSC Differentiation for Adolescents

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dc.citation.volume2019
dc.contributor.authorXu W
dc.contributor.authorLi J
dc.contributor.authorLi J
dc.contributor.authorYang J-J
dc.contributor.authorWang Q
dc.contributor.authorLiu B
dc.contributor.authorQiu W
dc.contributor.editorBallini A
dc.coverage.spatialUnited States
dc.date.accessioned2024-01-29T01:15:01Z
dc.date.accessioned2024-07-25T06:50:00Z
dc.date.available2019-04-04
dc.date.available2024-01-29T01:15:01Z
dc.date.available2024-07-25T06:50:00Z
dc.date.issued2019-04-04
dc.description.abstractDental pulp stem cells (DPSCs) have the property of self-renewal and multidirectional differentiation so that they have the potential for future regenerative therapy of various diseases. The latest breakthrough in the biology of stem cells and the development of regenerative biology provides an effective strategy for regenerative therapy. However, in the medium promoting differentiation during long-term passage, DPSCs would lose their differentiation capability. Some efforts have been made to find genes influencing human DPSC (hDPSC) differentiation based on hDPSCs isolated from adults. However, hDPSC differentiation is a very complex process, which involves multiple genes and multielement interactions. The purpose of this study is to detect sets of correlated genes (i.e., gene modules) that are associated to hDPSC differentiation at the crown-completed stage of the third molars, by using weighted gene coexpression network analysis (WGCNA). Based on the gene expression dataset GSE10444 from Gene Expression Omnibus (GEO), we identified two significant gene modules: yellow module (742 genes) and salmon module (9 genes). The WEB-based Gene SeT AnaLysis Toolkit showed that the 742 genes in the yellow module were enriched in 59 KEGG pathways (including Wnt signaling pathway), while the 9 genes in the salmon module were enriched in one KEGG pathway (neurotrophin signaling pathway). There were 660 (7) genes upregulated at P10 and 82 (2) genes downregulated at P10 in the yellow (salmon) module. Our results provide new insights into the differentiation capability of hDPSCs.
dc.description.confidentialfalse
dc.format.pagination8913287-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/31089336
dc.identifier.citationXu W, Li J, Li J, Yang J-J, Wang Q, Liu B, Qiu W. (2019). An Investigation about Gene Modules Associated with hDPSC Differentiation for Adolescents.. Stem Cells Int. 2019. (pp. 8913287-).
dc.identifier.doi10.1155/2019/8913287
dc.identifier.eissn1687-9678
dc.identifier.elements-typejournal-article
dc.identifier.issn1687-966X
dc.identifier.number8913287
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70969
dc.languageeng
dc.publisherHindawi Limited
dc.publisher.urihttps://www.hindawi.com/journals/sci/2019/8913287/
dc.relation.isPartOfStem Cells Int
dc.rights(c) The author/sen
dc.rights.licenseCC BY 4.0en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.titleAn Investigation about Gene Modules Associated with hDPSC Differentiation for Adolescents
dc.typeJournal article
pubs.elements-id446295
pubs.organisational-groupOther
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