Herzog is not required for mushroom body development or courtship learning & memory but is required for eye development in Drosophila melanogaster

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dc.citation.volume2023
dc.contributor.authorFitzsimons H
dc.contributor.authorPalmer MJ
dc.coverage.spatialUnited States
dc.date.available2023
dc.date.available2023-01-20
dc.date.issued30/01/2023
dc.descriptionCopyright: © 2023 by the authors.
dc.description.abstractHerzog (Hzg, CG5830) shares similarity to members of the haloacid dehalogenase subfamily of small CTD phosphatases. In Drosophila it is a maternal gene essential for establishment of embryonic segment polarity, and oligomerization is required for activation of phosphatase activity. While Hzg is expressed in the brain, its role has not been investigated. To that end, we further characterized Hzg expression in the brain and found that it is highly expressed in neurons of the mushroom body where it localises to axons, and is also expressed in cortical glia. We investigated its role in mushroom body development as well as courtship learning and memory, but found that knockdown of Hzg had no impact on these processes. In contrast, knockdown in post-mitotic neurons in the eye resulted in disruption to ommatidial patterning and pigmentation, indicating it plays an important role in eye development.
dc.description.publication-statusPublished online
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/36798589
dc.identifier.citationMicroPubl Biol, 2023, 2023
dc.identifier.doi10.17912/micropub.biology.000720
dc.identifier.eissn2578-9430
dc.identifier.elements-id459757
dc.identifier.harvestedMassey_Dark
dc.identifier.urihttps://hdl.handle.net/10179/18045
dc.languageeng
dc.relation.isPartOfMicroPubl Biol
dc.titleHerzog is not required for mushroom body development or courtship learning & memory but is required for eye development in Drosophila melanogaster
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Natural Sciences
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