Effects of Greenshell™ mussel intervention on biomarkers of cartilage metabolism, inflammatory markers and joint symptoms in overweight/obese postmenopausal women: A randomized, double-blind, and placebo-controlled trial

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dc.citation.volume9
dc.contributor.authorAbshirini M
dc.contributor.authorCoad J
dc.contributor.authorWolber FM
dc.contributor.authorvon Hurst P
dc.contributor.authorMiller MR
dc.contributor.authorTian HS
dc.contributor.authorKruger MC
dc.contributor.editorPozzuoli, A
dc.coverage.spatialSwitzerland
dc.date.accessioned2023-07-18T02:03:37Z
dc.date.accessioned2023-09-04T01:40:48Z
dc.date.available2022-12-05
dc.date.available2023-07-18T02:03:37Z
dc.date.available2023-09-04T01:40:48Z
dc.date.issued2022-12-05
dc.date.updated2023-07-17T04:02:59Z
dc.description© 2022 Abshirini, Coad, Wolber, von Hurst, Miller, Tian and Kruger. Ten_US
dc.description.abstractOBJECTIVE: To investigate the effect of whole greenshell mussel (GSM) powder on biomarkers of cartilage metabolism, inflammatory cytokines, and joint symptoms in postmenopausal women with overweight/obesity and joint discomfort. DESIGN: Fifty-five postmenopausal women with overweight/obesity were randomly assigned to receive 3 g/day whole GSM powder or placebo for 12 weeks. Cartilage turnover biomarkers urinary C-telopeptide of type II collagen (CTX-II) and serum cartilage oligomeric matrix protein (COMP) were measured at baseline, week 6 and 12. Plasma cytokines were measured at baseline and week 12. Joint pain and knee-related problems were assessed at baseline and week 12 using a 100 mm Visual Analogue Scale (VAS) and the Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire, respectively. RESULTS: Forty-nine participants completed the study (GSM n = 25, placebo n = 24). After 12 weeks, urinary CTX-II showed no significant change over time or between the groups (interaction effect P = 0.1). However, in women with symptomatic knees, a significant difference was noted between the group (treatment effect P = 0.04), as it was lower in the GSM group compared to placebo group at week 6 (P = 0.04) and week 12 (P = 0.03). Serum COMP and plasma cytokines were not affected. GSM supplementation showed greater reduction in the VAS pain score than placebo (-13.2 ± 20.3 vs. -2.9 ± 15.9; P = 0.04). No significant change in KOOS domains between the two groups was observed. CONCLUSION: Oral supplementation of whole GSM powder at 3 g/day may slow down the degradation of type II collagen in postmenopausal women with symptomatic knees. GSM treatment conferred clinical benefit on overall joint pain. No significant effect was noted for inflammatory cytokines, suggesting that GSM may act within the joint microenvironment rather than at the systemic level. CLINICAL TRIAL REGISTRATION: [www.australianclinicaltrials.gov.au/clinical-trialregistries], identifier [ACTRN12620000413921p].
dc.description.confidentialfalse
dc.format.extent1063336-
dc.identifier1063336
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/36544504
dc.identifier.citationAbshirini M, Coad J, Wolber FM, von Hurst P, Miller MR, Tian HS, Kruger MC. (2022). Effects of Greenshell™ mussel intervention on biomarkers of cartilage metabolism, inflammatory markers and joint symptoms in overweight/obese postmenopausal women: A randomized, double-blind, and placebo-controlled trial.. Front Med (Lausanne). 9. (pp. 1063336-).
dc.identifier.doi10.3389/fmed.2022.1063336
dc.identifier.eissn2296-858X
dc.identifier.elements-typejournal-article
dc.identifier.harvestedMassey_Dark
dc.identifier.issn2296-858X
dc.identifier.urihttp://hdl.handle.net/10179/19882
dc.languageeng
dc.publisherFrontiers Media S A
dc.publisher.urihttps://www.frontiersin.org/articles/10.3389/fmed.2022.1063336/full
dc.relation.isPartOfFront Med (Lausanne)
dc.rightsCC BY 4.0en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectbiomarker
dc.subjectgreenshell mussel
dc.subjectinflammation
dc.subjectjoint pain
dc.subjectosteoarthritis
dc.titleEffects of Greenshell™ mussel intervention on biomarkers of cartilage metabolism, inflammatory markers and joint symptoms in overweight/obese postmenopausal women: A randomized, double-blind, and placebo-controlled trial
dc.typeJournal article
pubs.elements-id458613
pubs.organisational-groupOther
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