Evaluation of fully oxidised β-carotene as a feed ingredient to reduce bacterial infection and somatic cell counts in pasture-fed cows with subclinical mastitis

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dc.citation.issue5
dc.citation.volume69
dc.contributor.authorMcDougall S
dc.coverage.spatialEngland
dc.date.accessioned2024-02-02T02:22:29Z
dc.date.accessioned2024-07-25T06:32:03Z
dc.date.available2021-06-09
dc.date.available2024-02-02T02:22:29Z
dc.date.available2024-07-25T06:32:03Z
dc.date.issued2021-09
dc.description.abstractAIMS: To assess the effect of oral supplementation with fully oxidised β-carotene (OxBC) on bacteriological cure, the incidence of clinical mastitis, and somatic cell counts (SCC) in pasture-fed cows with subclinical intramammary infection. METHODS: Cows from four dairy herds were enrolled in early lactation if they had quarter-level SCC >200,000 cells/mL and they had a recognised bacterial intramammary pathogen in one or more quarters. They were randomly assigned to be individually fed from Day 0, for a mean of 40 days, with 0.5 kg of a cereal-based supplementary feed that either contained 300 mg of OxBC (treatment; n = 129 quarters) or did not (control; n = 135 quarters). Quarter-milk samples were collected on Days 21 and 42 for microbiology and SCC assessment. Bacteriological cure was defined as having occurred when the bacteria present on Day 0 were not isolated from samples collected on Days 21 or 42. A new intramammary infection was defined as a bacterial species isolated either on Day 21 or 42 differing from that isolated on Day 0. Clinical mastitis was diagnosed and recorded by herdowners up to Day 42. RESULTS: The bacteriological cure rate was greater for quarters from cows in the treatment group (13.9 (95% CI = 4.1-23.7)%) than for cows in the control group (6.9 (95% CI = 4.8-9.1)%; p = 0.02). The percentage of quarters that developed a new intramammary infection at Day 21 or 42 was greater for cows in the treatment group (17.9 (95% CI = 6.7-29.1)%) than for cows in the control group (13.0 (95% CI = 4.3-21.8)%; p < 0.01). The prevalence of quarters that were infected on Day 42 was less in cows in the treatment group (79.9 (95% CI = 62.3-97.6)%) than the control group (88.2 (95% CI = 78.4-97.9)%; p = 0.009). The incidence of quarters diagnosed with clinical mastitis by Day 42 was lower in cows from the treatment group (1/129 (0.78 (95% CI = 0.02-4.24)%)) than in cows from the control group (6/135 (4.44 (95% CI = 1.65-9.42)%; p = 0.03)). Mean quarter-level SCC was not statistically different between treatment groups (p = 0.34). CONCLUSIONS AND CLINICAL RELEVANCE: Feeding 300 mg/cow/day of OxBC resulted in a higher bacteriological cure rate, a lower prevalence of intramammary infection, and a lower incidence of clinical mastitis compared to untreated controls. However new intramammary infections increased in treated cows, and the magnitude of the increased bacteriological cure was low, resulting in 80% of cows remaining infected at Day 42. Therefore treatment with OxBC should be considered as an adjunct to other mastitis control measures.
dc.description.confidentialfalse
dc.format.pagination285-293
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/33944703
dc.identifier.citationMcDougall S. (2021). Evaluation of fully oxidised β-carotene as a feed ingredient to reduce bacterial infection and somatic cell counts in pasture-fed cows with subclinical mastitis.. N Z Vet J. 69. 5. (pp. 285-293).
dc.identifier.doi10.1080/00480169.2021.1924091
dc.identifier.eissn1176-0710
dc.identifier.elements-typejournal-article
dc.identifier.issn0048-0169
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70367
dc.languageeng
dc.publisherTaylor and Francis Group on behalf of the New Zealand Veterinary Association
dc.publisher.urihttps://www.tandfonline.com/doi/full/10.1080/00480169.2021.1924091
dc.relation.isPartOfN Z Vet J
dc.rights(c) The author/sen
dc.rights.licenseCC BY-NC-ND 4.0en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectOxidised β-carotene
dc.subjectcure
dc.subjectdairy cow
dc.subjectintramammary infection
dc.subjectprevalence
dc.subjectAnimals
dc.subjectAnti-Bacterial Agents
dc.subjectBacterial Infections
dc.subjectCattle
dc.subjectCattle Diseases
dc.subjectCell Count
dc.subjectFemale
dc.subjectLactation
dc.subjectMammary Glands, Animal
dc.subjectMastitis
dc.subjectMastitis, Bovine
dc.subjectMilk
dc.subjectbeta Carotene
dc.titleEvaluation of fully oxidised β-carotene as a feed ingredient to reduce bacterial infection and somatic cell counts in pasture-fed cows with subclinical mastitis
dc.typeJournal article
pubs.elements-id446794
pubs.organisational-groupOther
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