Pesticide exposure in New Zealand school-aged children: Urinary concentrations of biomarkers and assessment of determinants

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dc.citation.volume163
dc.contributor.authorLi Y
dc.contributor.authorWang X
dc.contributor.authorFeary McKenzie J
dc.contributor.author't Mannetje A
dc.contributor.authorCheng S
dc.contributor.authorHe C
dc.contributor.authorLeathem J
dc.contributor.authorPearce N
dc.contributor.authorSunyer J
dc.contributor.authorEskenazi B
dc.contributor.authorYeh R
dc.contributor.authorAylward LL
dc.contributor.authorDonovan G
dc.contributor.authorMueller JF
dc.contributor.authorDouwes J
dc.coverage.spatialNetherlands
dc.date.accessioned2023-06-28T21:00:28Z
dc.date.available2022-03-22
dc.date.available2023-06-28T21:00:28Z
dc.date.issued2022-05
dc.description© 2022 The Author(s)
dc.description.abstractThis study aimed to assess pesticide exposure and its determinants in children aged 5-14 years. Urine samples (n = 953) were collected from 501 participating children living in urban areas (participant n = 300), rural areas but not on a farm (n = 76), and living on a farm (n = 125). The majority provided two samples, one in the high and one in the low spraying season. Information on diet, lifestyle, and demographic factors was collected by questionnaire. Urine was analysed for 20 pesticide biomarkers by GC-MS/MS and LC-MS/MS. Nine analytes were detected in > 80% of samples, including six organophosphate insecticide metabolites (DMP, DMTP, DEP, DETP, TCPy, PNP), two pyrethroid insecticide metabolites (3-PBA, trans-DCCA), and one herbicide (2,4-D). The highest concentration was measured for TCPy (median 13 μg/g creatinine), a metabolite of chlorpyrifos and triclopyr, followed by DMP (11 μg/g) and DMTP (3.7 μg/g). Urine metabolite levels were generally similar or low compared to those reported for other countries, while relatively high for TCPy and pyrethroid metabolites. Living on a farm was associated with higher TCPy levels during the high spray season. Living in rural areas, dog ownership and in-home pest control were associated with higher levels of pyrethroid metabolites. Urinary concentrations of several pesticide metabolites were higher during the low spraying season, possibly due to consumption of imported fruits and vegetables. Organic fruit consumption was not associated with lower urine concentrations, but consumption of organic food other than fruit or vegetables was associated with lower concentrations of TCPy in the high spray season. In conclusion, compared to other countries such as the U.S., New Zealand children had relatively high exposures to chlorpyrifos/triclopyr and pyrethroids. Factors associated with exposure included age, season, area of residence, diet, in-home pest control, and pets.
dc.description.publication-statusPublished
dc.format.extent107206 - ?
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/35395578
dc.identifierS0160-4120(22)00132-5
dc.identifier.citationEnviron Int, 2022, 163 pp. 107206 - ?
dc.identifier.doi10.1016/j.envint.2022.107206
dc.identifier.eissn1873-6750
dc.identifier.elements-id452824
dc.identifier.harvestedMassey_Dark
dc.identifier.urihttps://hdl.handle.net/10179/18359
dc.languageeng
dc.publisherElsevier Ltd
dc.relation.isPartOfEnviron Int
dc.subjectChildren
dc.subjectHuman biomonitoring
dc.subjectOrganophosphates
dc.subjectPyrethroids
dc.subjectRisk factors
dc.subjectAnimals
dc.subjectBiomarkers
dc.subjectChild
dc.subjectChlorpyrifos
dc.subjectChromatography, Liquid
dc.subjectDogs
dc.subjectEnvironmental Exposure
dc.subjectHumans
dc.subjectInsecticides
dc.subjectNew Zealand
dc.subjectPesticides
dc.subjectPyrethrins
dc.subjectTandem Mass Spectrometry
dc.titlePesticide exposure in New Zealand school-aged children: Urinary concentrations of biomarkers and assessment of determinants
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Health
pubs.organisational-group/Massey University/College of Health/Research Centre for Hauora and Health
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