VEGF-A related SNPs: a cardiovascular context.

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dc.citation.volume10
dc.contributor.authorMeza-Alvarado JC
dc.contributor.authorPage RA
dc.contributor.authorMallard B
dc.contributor.authorBromhead C
dc.contributor.authorPalmer BR
dc.coverage.spatialSwitzerland
dc.date.accessioned2023-06-15T20:53:01Z
dc.date.available2023
dc.date.available2023-04-27
dc.date.available2023-06-15T20:53:01Z
dc.date.issued2023
dc.description© 2023 Meza-Alvarado, Page, Mallard, Bromhead and Palmer
dc.description.abstractCardiovascular diseases (CVDs) are the leading cause of death worldwide. Currently, cardiovascular disease risk algorithms play a role in primary prevention. However, this is complicated by a lack of powerfully predictive biomarkers that could be observed in individuals before the onset of overt symptoms. A key potential biomarker for heart disease is the vascular endothelial growth factor (VEGF-A), a molecule that plays a pivotal role in blood vessel formation. This molecule has a complex biological role in the cardiovascular system due to the processes it influences, and its production is impacted by various CVD risk factors. Research in different populations has shown single nucleotide polymorphisms (SNPs) may affect circulating VEGF-A plasma levels, with some variants associated with the development of CVDs, as well as CVD risk factors. This minireview aims to give an overview of the VEGF family, and of the SNPs reported to influence VEGF-A levels, cardiovascular disease, and other risk factors used in CVD risk assessments.
dc.description.publication-statusPublished online
dc.format.extent1190513 - ?
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/37288254
dc.identifier.citationFront Cardiovasc Med, 2023, 10 pp. 1190513 - ?
dc.identifier.doi10.3389/fcvm.2023.1190513
dc.identifier.elements-id462074
dc.identifier.harvestedMassey_Dark
dc.identifier.issn2297-055X
dc.identifier.urihttps://hdl.handle.net/10179/18297
dc.languageeng
dc.relation.isPartOfFront Cardiovasc Med
dc.subjectVEGF-A eQTLs
dc.subjectcardiovascular disease
dc.subjectgenetic association
dc.subjectsingle nucleotide polymorphism
dc.subjectvascular endothelial growth factor
dc.titleVEGF-A related SNPs: a cardiovascular context.
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Health
pubs.organisational-group/Massey University/College of Health/PVC's Office - College of Health
pubs.organisational-group/Massey University/College of Health/School of Health Science
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