Plasma nervonic acid levels were negatively associated with attention levels in community-living older adults in New Zealand

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dc.citation.issue8
dc.citation.volume18
dc.contributor.authorde Seymour JV
dc.contributor.authorBeck KL
dc.contributor.authorConlon CA
dc.contributor.authorVon Hurst PR
dc.contributor.authorMumme KD
dc.contributor.authorHaskell-Ramsay CF
dc.contributor.authorJones MB
dc.coverage.spatialUnited States
dc.date.accessioned2023-08-28T03:26:11Z
dc.date.accessioned2023-09-04T01:41:29Z
dc.date.available2022-07-16
dc.date.available2023-08-28T03:26:11Z
dc.date.available2023-09-04T01:41:29Z
dc.date.issued2022-08
dc.date.updated2023-08-18T01:52:32Z
dc.description© The Author(s) 2022en_US
dc.description.abstractThe global population is aging. Preserving function and independence of our aging population is paramount. A key component to maintaining independence is the preservation of cognitive function. Metabolomics can be used to identify biomarkers of cognition before noticeable deterioration. Our study investigated the plasma metabolome of 332 community-living New Zealanders between 65 and 74 years of age, using gas chromatography-mass spectrometry. Six cognitive domains were assessed. Of the 123 metabolites identified using an in-house mass spectral libraries of standards, nervonic acid had a significant, inverse association with the attention domain (P-value = 1.52E− 4; FDR = 0.019), after adjusting for covariates (apolipoprotein E -ε4 genotype, sex, body fat percentage (standardised by sex), age, education, deprivation index, physical activity, metabolic syndrome, polypharmacy, smoking status, and alcohol intake) and multiple testing. Attention is defined as the ability to concentrate on selected aspects of the environment while ignoring other stimuli. This is the first study to identify nervonic acid as a potential biomarker of attention in older adults. Future research should confirm this association in a longitudinal study.
dc.format.extent54-
dc.identifier10.1007/s11306-022-01908-5
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/35842880
dc.identifier.citationde Seymour JV, Beck KL, Conlon CA, von Hurst PR, Mumme KD, Haskell-Ramsay CF, Jones MB. (2022). Plasma nervonic acid levels were negatively associated with attention levels in community-living older adults in New Zealand.. Metabolomics. 18. 8. (pp. 54-).
dc.identifier.doi10.1007/s11306-022-01908-5
dc.identifier.eissn1573-3890
dc.identifier.elements-typejournal-article
dc.identifier.harvestedMassey_Dark
dc.identifier.issn1573-3882
dc.identifier.urihttp://hdl.handle.net/10179/19976
dc.languageeng
dc.publisherSpringer Nature
dc.relation.isPartOfMetabolomics
dc.rightsCC BY 4.0en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectCognition
dc.subjectHealthy aging
dc.subjectMass spectrometry
dc.subjectMetabolite
dc.subjectMetabolomics
dc.subjectAged
dc.subjectApolipoprotein E4
dc.subjectAttention
dc.subjectBiomarkers
dc.subjectFatty Acids, Monounsaturated
dc.subjectHumans
dc.subjectLongitudinal Studies
dc.subjectMetabolomics
dc.subjectNew Zealand
dc.titlePlasma nervonic acid levels were negatively associated with attention levels in community-living older adults in New Zealand
dc.typeJournal article
pubs.elements-id454740
pubs.organisational-groupOther
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