Lipidomics of Brain Tissues in Rats Fed Human Milk from Chinese Mothers or Commercial Infant Formula

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dc.citation.issue11
dc.citation.volume9
dc.contributor.authorSu M
dc.contributor.authorSubbaraj AK
dc.contributor.authorFraser K
dc.contributor.authorQi X
dc.contributor.authorJia H
dc.contributor.authorChen W
dc.contributor.authorGomes Reis M
dc.contributor.authorAgnew M
dc.contributor.authorDay L
dc.contributor.authorRoy NC
dc.contributor.authorYoung W
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-10-18T01:34:23Z
dc.date.available2024-10-18T01:34:23Z
dc.date.issued2019-10-28
dc.description.abstractHolistic benefits of human milk to infants, particularly brain development and cognitive behavior, have stipulated that infant formula be tailored in composition like human milk. However, the composition of human milk, especially lipids, and their effects on brain development is complex and not fully elucidated. We evaluated brain lipidome profiles in weanling rats fed human milk or infant formula using non-targeted UHPLC-MS techniques. We also compared the lipid composition of human milk and infant formula using conventional GC-FID and HPLC-ELSD techniques. The sphingomyelin class of lipids was significantly higher in brains of rats fed human milk. Lipid species mainly comprising saturated or mono-unsaturated C18 fatty acids contributed significantly higher percentages to their respective classes in human milk compared to infant formula fed samples. In contrast, PUFAs contributed significantly higher percentages in brains of formula fed samples. Differences between human milk and formula lipids included minor fatty acids such as C8:0 and C12:0, which were higher in formula, and C16:1 and C18:1 n11, which were higher in human milk. Formula also contained higher levels of low- to medium-carbon triacylglycerols, whereas human milk had higher levels of high-carbon triacylglycerols. All phospholipid classes, and ceramides, were higher in formula. We show that brain lipid composition differs in weanling rats fed human milk or infant formula, but dietary lipid compositions do not necessarily manifest in the brain lipidome.
dc.description.confidentialfalse
dc.edition.editionNovember 2019
dc.format.paginationE253-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/31661817
dc.identifier.citationSu M, Subbaraj AK, Fraser K, Qi X, Jia H, Chen W, Gomes Reis M, Agnew M, Day L, Roy NC, Young W. (2019). Lipidomics of Brain Tissues in Rats Fed Human Milk from Chinese Mothers or Commercial Infant Formula.. Metabolites. 9. 11. (pp. E253-).
dc.identifier.doi10.3390/metabo9110253
dc.identifier.eissn2218-1989
dc.identifier.elements-typejournal-article
dc.identifier.issn2218-1989
dc.identifier.numberARTN 253
dc.identifier.piimetabo9110253
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71760
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2218-1989/9/11/253
dc.relation.isPartOfMetabolites
dc.rights(c) 2019 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectbrain
dc.subjectcomposition
dc.subjecthuman milk
dc.subjectinfant formula
dc.subjectlipidomics
dc.subjectlipids
dc.subjectrat
dc.titleLipidomics of Brain Tissues in Rats Fed Human Milk from Chinese Mothers or Commercial Infant Formula
dc.typeJournal article
pubs.elements-id434464
pubs.organisational-groupOther
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