The Gut Microbiome Is Altered in Postmenopausal Women With Osteoporosis and Osteopenia

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dc.citation.issue3
dc.citation.volume5
dc.contributor.authorRettedal EA
dc.contributor.authorIlesanmi-Oyelere BL
dc.contributor.authorRoy NC
dc.contributor.authorCoad J
dc.contributor.authorKruger MC
dc.coverage.spatialEngland
dc.date.accessioned2023-07-12T02:03:34Z
dc.date.accessioned2023-09-04T01:40:42Z
dc.date.available2020-12-14
dc.date.available2023-07-12T02:03:34Z
dc.date.available2023-09-04T01:40:42Z
dc.date.issued2021-03-24
dc.date.updated2023-07-11T04:19:38Z
dc.description(c) 2020 The Author/s
dc.description.abstractOsteoporosis and its precursor osteopenia are common metabolic bone diseases in postmenopausal women. A growing body of evidence suggests that the gut microbiota is involved in the regulation of bone metabolism; however, there are few studies examining how gut microbiomes in osteoporosis and osteopenia may differ from those in healthy individuals. The aim of this study was to characterize the diversity, composition, and functional gene potential of the gut microbiota of healthy, osteopenic, and osteoporotic women. Body composition, bone density, and fecal metagenomes were analyzed in 86 postmenopausal women. The women were classified as healthy, osteopenic, or osteoporotic based on T-scores. The taxonomic and functional gene compositions of the microbiome were analyzed using shotgun metagenomic sequencing. Both osteoporotic and osteopenic taxonomic compositions were found to be significantly different from healthy participants. Linear discriminant-analysis effect-size analyses identified that healthy participants had more unclassified Clostridia and methanogenic archaea (Methanobacteriaceae) than in both osteoporotic and osteopenic participants. Bacteroides was found to be more abundant in osteoporosis and osteopenia groups. Some KEGG pathways, including carbohydrate metabolism, biosynthesis of secondary metabolites, and cyanoamino acid metabolism, were found to be more abundant in both osteoporosis and osteopenia. These results show that osteoporosis and osteopenia alter the gut microbiome of postmenopausal women and identify potential microbial taxonomic and functional pathways that may be involved in this disease.
dc.description.confidentialfalse
dc.edition.editionMarch 2021
dc.format.extente10452-
dc.identifiere10452
dc.identifierJBM410452
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/33778322
dc.identifier.citationRettedal EA, Ilesanmi-Oyelere BL, Roy NC, Coad J, Kruger MC. (2021). The Gut Microbiome Is Altered in Postmenopausal Women With Osteoporosis and Osteopenia.. JBMR Plus. 5. 3. (pp. e10452-).
dc.identifier.doi10.1002/jbm4.10452
dc.identifier.eissn2473-4039
dc.identifier.elements-typejournal-article
dc.identifier.harvestedMassey_Dark
dc.identifier.issn2473-4039
dc.identifier.urihttp://hdl.handle.net/10179/19867
dc.languageeng
dc.publisherWiley Periodicals LLC on behalf of American Society for Bone and Mineral Research
dc.publisher.urihttps://asbmr.onlinelibrary.wiley.com/doi/10.1002/jbm4.10452
dc.relation.isPartOfJBMR Plus
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectDISEASES AND DISORDERS OF/RELATED TO BONE
dc.subjectMENOPAUSE
dc.subjectOSTEOPOROSIS
dc.subjectOTHER THERAPEUTICS
dc.titleThe Gut Microbiome Is Altered in Postmenopausal Women With Osteoporosis and Osteopenia
dc.typeJournal article
pubs.elements-id438397
pubs.organisational-groupOther
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