Effects of a single subcutaneous dose of enoxaparin on veterinary viscoelastic coagulation monitor variables in healthy cats: Double blind, placebo controlled cross-over trial

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dc.citation.issue1
dc.citation.volume37
dc.contributor.authorYozova I
dc.contributor.authorKent M
dc.contributor.authorJandrey K
dc.coverage.spatialUnited States
dc.date.available2023-01
dc.date.available2022-11-23
dc.date.issued10/12/2022
dc.description(c) The Author/s
dc.description.abstractBACKGROUND: Cats placed on anticoagulant medication require frequent monitoring. The veterinary viscoelastic coagulation monitor (VCM-Vet) could provide a convenient and cost-effective monitoring, enabling therapeutic decision making. HYPOTHESIS/OBJECTIVES: Enoxaparin will lead to changes in VCM-Vet variables and these will correlate with antiXa activity. ANIMALS: Twenty-one healthy cats. METHODS: Cats were randomized to receive either enoxaparin (1 mg/kg) subcutaneously or 0.9% NaCl (equal volume) and crossed over with a 7-day washout period. The investigators were blinded to group allocation until data analysis. Jugular blood samples were drawn at time 0, and 2, 4, and 8 hours after injection for VCM-Vet analysis within 2 min of collection. Citrated plasma was frozen at -80°C for antiXa activity analysis. A Generalized Linear Model was completed to assess changes between baseline measurements and all time points. RESULTS: Significant differences between the enoxaparin-treated cats and controls at for T0h and T2h were found and presented as mean ± SD for clotting time (enoxaparin, 593.4 ± 78.0 s; control, 448.5 ± 50.3 s, P < .001), clot formation time (enoxaparin, 183.1 ± 41.7 s; control, 155.4 ± 28.0 s, P = .001), and alpha angle (enoxaparin, 52.4 ± 6.1°; control, 56.9 ± 3.7 s, P = .003). AntiXa activity was significantly different between T0 and all other timepoints for the enoxaparin group (P < .001). There was no correlation between changes in clotting time and antiXa activity. CONCLUSIONS AND CLINICAL IMPORTANCE: The VCM-Vet detects a difference at 2 hours after single-dose enoxaparin administration and it can be useful for anticoagulant therapy monitoring in cats.
dc.description.publication-statusPublished
dc.format.extent133 - 139
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/36495054
dc.identifier.citationJ Vet Intern Med, 2023, 37 (1), pp. 133 - 139
dc.identifier.doi10.1111/jvim.16602
dc.identifier.eissn1939-1676
dc.identifier.elements-id458483
dc.identifier.harvestedMassey_Dark
dc.identifier.urihttps://hdl.handle.net/10179/17883
dc.languageeng
dc.publisherWiley Open Access
dc.relation.isPartOfJ Vet Intern Med
dc.subjectcage-side
dc.subjectheparin
dc.subjectpoint-of-care
dc.subjectviscoelastic coagulation testing
dc.subjectCats
dc.subjectAnimals
dc.subjectEnoxaparin
dc.subjectCross-Over Studies
dc.subjectAnticoagulants
dc.subjectBlood Coagulation
dc.subjectBlood Coagulation Tests
dc.subject.anzsrc0707 Veterinary Sciences
dc.titleEffects of a single subcutaneous dose of enoxaparin on veterinary viscoelastic coagulation monitor variables in healthy cats: Double blind, placebo controlled cross-over trial
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Veterinary Science
pubs.organisational-group/Massey University/College of Sciences/School of Veterinary Science/Veterinary Clinic & Teaching Hospital
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