Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes

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dc.citation.issue7
dc.citation.volume16
dc.contributor.authorPalmer BR
dc.contributor.authorPaterson MA
dc.contributor.authorFrampton CM
dc.contributor.authorPilbrow AP
dc.contributor.authorSkelton L
dc.contributor.authorPemberton CJ
dc.contributor.authorDoughty RN
dc.contributor.authorEllis CJ
dc.contributor.authorTroughton RW
dc.contributor.authorRichards AM
dc.contributor.authorCameron VA
dc.contributor.editorZirlik A
dc.coverage.spatialUnited States
dc.date.accessioned2023-07-27T20:06:57Z
dc.date.accessioned2023-09-04T01:40:53Z
dc.date.available2021-07-14
dc.date.available2023-07-27T20:06:57Z
dc.date.available2023-09-04T01:40:53Z
dc.date.issued2021-07-14
dc.date.updated2023-07-24T22:20:29Z
dc.descriptionThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.description.abstractBACKGROUND: Development of a competent collateral circulation in established coronary artery disease is cardio-protective. The vascular endothelial growth factor (VEGF) system plays a key role in this process. We investigated the prognostic performance of circulating VEGF-A and three genetic variants in the VEGFA gene in a clinical coronary cohort. METHODS AND RESULTS: The Coronary Disease Cohort Study (CDCS) recruited 2,140 patients, with a diagnosis of acute coronary syndrome (ACS), after admission to Christchurch or Auckland City Hospitals between July 2002 and January 2009. We present data for 1927 patients from the cohort genotyped for three SNPs in the VEGF-A gene, rs699947 (C-2578A), rs2010963 (C405G) and rs3025039 (C936T). Plasma VEGF-A concentrations were assayed in a subgroup (n = 550) of CDCS patients (geometric mean 36.6 [34.7-38.5] pg/ml). VEGF-A levels correlated with patient heart rate at baseline (p = 0.034). None of rs699947, rs3025039, nor rs2010963 genotypes were significantly associated with VEGF-A levels, but rs3025039 genotype was positively associated with collateral vessels perfusion according to the Rentrop classification (p = 0.01) and baseline natriuretic peptide levels (p<0.05). Survival in the CDCS cohort was independently associated with baseline VEGF-A levels and (in males) with rs699947 genotype. CONCLUSIONS: This study is strongly suggestive that VEGF-A levels have value as a prognostic biomarker in coronary heart disease patients and SNPs in VEGF-A deserve further investigation as prognostic markers and indicators of angiogenic potential influencing the formation of collateral circulation.
dc.description.confidentialfalse
dc.description.notesPalmer, Barry R Paterson, Melinda A Frampton, Chris M Pilbrow, Anna P Skelton, Lorraine Pemberton, Chris J Doughty, Robert N Ellis, Chris J Troughton, Richard W Richards, A Mark Cameron, Vicky A eng PLoS One. 2021 Jul 14;16(7):e0254206. doi: 10.1371/journal.pone.0254206. eCollection 2021. BACKGROUND: Development of a competent collateral circulation in established coronary artery disease is cardio-protective. The vascular endothelial growth factor (VEGF) system plays a key role in this process. We investigated the prognostic performance of circulating VEGF-A and three genetic variants in the VEGFA gene in a clinical coronary cohort. METHODS AND RESULTS: The Coronary Disease Cohort Study (CDCS) recruited 2,140 patients, with a diagnosis of acute coronary syndrome (ACS), after admission to Christchurch or Auckland City Hospitals between July 2002 and January 2009. We present data for 1927 patients from the cohort genotyped for three SNPs in the VEGF-A gene, rs699947 (C-2578A), rs2010963 (C405G) and rs3025039 (C936T). Plasma VEGF-A concentrations were assayed in a subgroup (n = 550) of CDCS patients (geometric mean 36.6 [34.7-38.5] pg/ml). VEGF-A levels correlated with patient heart rate at baseline (p = 0.034). None of rs699947, rs3025039, nor rs2010963 genotypes were significantly associated with VEGF-A levels, but rs3025039 genotype was positively associated with collateral vessels perfusion according to the Rentrop classification (p = 0.01) and baseline natriuretic peptide levels (p<0.05). Survival in the CDCS cohort was independently associated with baseline VEGF-A levels and (in males) with rs699947 genotype. CONCLUSIONS: This study is strongly suggestive that VEGF-A levels have value as a prognostic biomarker in coronary heart disease patients and SNPs in VEGF-A deserve further investigation as prognostic markers and indicators of angiogenic potential influencing the formation of collateral circulation.
dc.format.extente0254206-
dc.identifierARTN e0254206
dc.identifierPONE-D-20-21998
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/34260629
dc.identifier.citationPalmer BR, Paterson MA, Frampton CM, Pilbrow AP, Skelton L, Pemberton CJ, Doughty RN, Ellis CJ, Troughton RW, Richards AM, Cameron VA. (2021). Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes.. PLoS One. 16. 7. (pp. e0254206-).
dc.identifier.doi10.1371/journal.pone.0254206
dc.identifier.eissn1932-6203
dc.identifier.elements-typejournal-article
dc.identifier.harvestedMassey_Dark
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10179/19893
dc.languageeng
dc.publisherPLOS
dc.publisher.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254206
dc.relation.isPartOfPLoS One
dc.rights(c) The author/s CC BY 4.0en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectAcute Coronary Syndrome
dc.subjectCohort Studies
dc.subjectHumans
dc.subjectMiddle Aged
dc.subjectPolymorphism, Single Nucleotide
dc.subjectVascular Endothelial Growth Factor A
dc.titleVascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes
dc.typeJournal article
pubs.elements-id447296
pubs.organisational-groupOther
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