Green-lipped (greenshell™) mussel (Perna canaliculus) extract supplementation in treatment of osteoarthritis: a systematic review

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dc.citation.issue4
dc.citation.volume29
dc.contributor.authorAbshirini M
dc.contributor.authorCoad J
dc.contributor.authorWolber FM
dc.contributor.authorVon Hurst P
dc.contributor.authorMiller MR
dc.contributor.authorTian HS
dc.contributor.authorKruger MC
dc.coverage.spatialSwitzerland
dc.date.accessioned2023-07-18T02:56:21Z
dc.date.accessioned2023-09-04T01:40:46Z
dc.date.available2021-03-18
dc.date.available2023-07-18T02:56:21Z
dc.date.available2023-09-04T01:40:46Z
dc.date.issued2021-08
dc.date.updated2023-07-16T23:31:12Z
dc.description.abstractOBJECTIVES: Intervention studies using New Zealand green-lipped or greenshell™ mussel (GSM) (Perna canaliculus) extract in osteoarthritis (OA) patients have shown effective pain relief. This systematic review summarises the efficacy of GSM extracts in the treatment of OA. METHODS: A literature search of the three databases EMBASE, MEDLINE, and Scopus was performed to identify relevant articles published up to March 2020. Inclusion criteria were clinical trials published in English measuring the effect of supplementation of whole or a lipid extract from GSM on pain and mobility outcomes in OA patients. RESULTS: A total of nine clinical trials were included in systematic review, from which five studies were considered appropriate for inclusion in a forest plot. Pooled results showed that GSM extracts (lipid extract or whole powder) provide moderate and clinically significant treatment effects on a visual analogue scale (VAS) pain score (effect size: - 0.46; 95% CI - 0.82 to - 0.10; p = 0.01). The whole GSM extract improved gastrointestinal symptoms in OA patients taking anti-inflammatory medications. The GSM extract was considered to be generally well tolerated in most of the studies. CONCLUSION: The overall analysis showed that GSM provided moderate and clinically meaningful treatment effects on OA pain. However, the current evidence is limited by the number and quality of studies, and further larger and high-quality studies are needed to confirm the effectiveness and to identify the optimal GSM format. Nevertheless, it is worth considering using GSM extracts especially for patients seeking alternative pain relief treatments with fewer side effects compared to conventional treatment.
dc.description.confidentialfalse
dc.edition.editionAugust 2021
dc.format.extent925-938
dc.identifier10.1007/s10787-021-00801-2
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/33738701
dc.identifier.citationAbshirini M, Coad J, Wolber FM, von Hurst P, Miller MR, Tian HS, Kruger MC. (2021). Green-lipped (greenshell™) mussel (Perna canaliculus) extract supplementation in treatment of osteoarthritis: a systematic review.. Inflammopharmacology. 29. 4. (pp. 925-938).
dc.identifier.doi10.1007/s10787-021-00801-2
dc.identifier.eissn1568-5608
dc.identifier.elements-typejournal-article
dc.identifier.harvestedMassey_Dark
dc.identifier.issn0925-4692
dc.identifier.urihttp://hdl.handle.net/10179/19876
dc.languageeng
dc.publisherSpringer Nature Switzerland AG
dc.publisher.urihttps://link.springer.com/article/10.1007/s10787-021-00801-2
dc.relation.isPartOfInflammopharmacology
dc.rightsCC BY 4.0en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectGreenshell mussel
dc.subjectJoint pain
dc.subjectOsteoarthritis
dc.subjectRandomized-controlled trial
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAnimals
dc.subjectBiological Factors
dc.subjectClinical Trials as Topic
dc.subjectDietary Supplements
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectOsteoarthritis
dc.subjectPain Measurement
dc.subjectPerna
dc.subjectTreatment Outcome
dc.titleGreen-lipped (greenshell™) mussel (Perna canaliculus) extract supplementation in treatment of osteoarthritis: a systematic review
dc.typeJournal article
pubs.elements-id441850
pubs.organisational-groupOther
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