Genome-wide interaction analysis of folate for colorectal cancer risk.

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dc.citation.issue5
dc.citation.volume118
dc.contributor.authorBouras E
dc.contributor.authorKim AE
dc.contributor.authorLin Y
dc.contributor.authorMorrison J
dc.contributor.authorDu M
dc.contributor.authorAlbanes D
dc.contributor.authorBarry EL
dc.contributor.authorBaurley JW
dc.contributor.authorBerndt SI
dc.contributor.authorBien SA
dc.contributor.authorBishop TD
dc.contributor.authorBrenner H
dc.contributor.authorBudiarto A
dc.contributor.authorBurnett-Hartman A
dc.contributor.authorCampbell PT
dc.contributor.authorCarreras-Torres R
dc.contributor.authorCasey G
dc.contributor.authorCenggoro TW
dc.contributor.authorChan AT
dc.contributor.authorChang-Claude J
dc.contributor.authorConti DV
dc.contributor.authorCotterchio M
dc.contributor.authorDevall M
dc.contributor.authorDiez-Obrero V
dc.contributor.authorDimou N
dc.contributor.authorDrew DA
dc.contributor.authorFigueiredo JC
dc.contributor.authorGiles GG
dc.contributor.authorGruber SB
dc.contributor.authorGunter MJ
dc.contributor.authorHarrison TA
dc.contributor.authorHidaka A
dc.contributor.authorHoffmeister M
dc.contributor.authorHuyghe JR
dc.contributor.authorJoshi AD
dc.contributor.authorKawaguchi ES
dc.contributor.authorKeku TO
dc.contributor.authorKundaje A
dc.contributor.authorLe Marchand L
dc.contributor.authorLewinger JP
dc.contributor.authorLi L
dc.contributor.authorLynch BM
dc.contributor.authorMahesworo B
dc.contributor.authorMännistö S
dc.contributor.authorMoreno V
dc.contributor.authorMurphy N
dc.contributor.authorNewcomb PA
dc.contributor.authorObón-Santacana M
dc.contributor.authorOse J
dc.contributor.authorPalmer JR
dc.contributor.authorPapadimitriou N
dc.contributor.authorPardamean B
dc.contributor.authorPellatt AJ
dc.contributor.authorPeoples AR
dc.contributor.authorPlatz EA
dc.contributor.authorPotter JD
dc.contributor.authorQi L
dc.contributor.authorQu C
dc.contributor.authorRennert G
dc.contributor.authorRuiz-Narvaez E
dc.contributor.authorSakoda LC
dc.contributor.authorSchmit SL
dc.contributor.authorShcherbina A
dc.contributor.authorStern MC
dc.contributor.authorSu Y-R
dc.contributor.authorTangen CM
dc.contributor.authorThomas DC
dc.contributor.authorTian Y
dc.contributor.authorUm CY
dc.contributor.authorvan Duijnhoven FJ
dc.contributor.authorVan Guelpen B
dc.contributor.authorVisvanathan K
dc.contributor.authorWang J
dc.contributor.authorWhite E
dc.contributor.authorWolk A
dc.contributor.authorWoods MO
dc.contributor.authorUlrich CM
dc.contributor.authorHsu L
dc.contributor.authorGauderman WJ
dc.contributor.authorPeters U
dc.contributor.authorTsilidis KK
dc.coverage.spatialUnited States
dc.date.accessioned2024-06-11T23:25:22Z
dc.date.available2024-06-11T23:25:22Z
dc.date.issued2023-11
dc.description.abstractBackground Epidemiological and experimental evidence suggests that higher folate intake is associated with decreased colorectal cancer (CRC) risk; however, the mechanisms underlying this relationship are not fully understood. Genetic variation that may have a direct or indirect impact on folate metabolism can provide insights into folate’s role in CRC. Objectives Our aim was to perform a genome-wide interaction analysis to identify genetic variants that may modify the association of folate on CRC risk. Methods We applied traditional case-control logistic regression, joint 3-degree of freedom, and a 2-step weighted hypothesis approach to test the interactions of common variants (allele frequency >1%) across the genome and dietary folate, folic acid supplement use, and total folate in relation to risk of CRC in 30,550 cases and 42,336 controls from 51 studies from 3 genetic consortia (CCFR, CORECT, GECCO). Results Inverse associations of dietary, total folate, and folic acid supplement with CRC were found (odds ratio [OR]: 0.93; 95% confidence interval [CI]: 0.90, 0.96; and 0.91; 95% CI: 0.89, 0.94 per quartile higher intake, and 0.82 (95% CI: 0.78, 0.88) for users compared with nonusers, respectively). Interactions (P-interaction < 5×10-8) of folic acid supplement and variants in the 3p25.2 locus (in the region of Synapsin II [SYN2]/tissue inhibitor of metalloproteinase 4 [TIMP4]) were found using traditional interaction analysis, with variant rs150924902 (located upstream to SYN2) showing the strongest interaction. In stratified analyses by rs150924902 genotypes, folate supplementation was associated with decreased CRC risk among those carrying the TT genotype (OR: 0.82; 95% CI: 0.79, 0.86) but increased CRC risk among those carrying the TA genotype (OR: 1.63; 95% CI: 1.29, 2.05), suggesting a qualitative interaction (P-interaction = 1.4×10-8). No interactions were observed for dietary and total folate. Conclusions Variation in 3p25.2 locus may modify the association of folate supplement with CRC risk. Experimental studies and studies incorporating other relevant omics data are warranted to validate this finding.
dc.description.confidentialfalse
dc.edition.editionNovember 2023
dc.format.pagination881-891
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37640106
dc.identifier.citationBouras E, Kim AE, Lin Y, Morrison J, Du M, Albanes D, Barry EL, Baurley JW, Berndt SI, Bien SA, Bishop TD, Brenner H, Budiarto A, Burnett-Hartman A, Campbell PT, Carreras-Torres R, Casey G, Cenggoro TW, Chan AT, Chang-Claude J, Conti DV, Cotterchio M, Devall M, Diez-Obrero V, Dimou N, Drew DA, Figueiredo JC, Giles GG, Gruber SB, Gunter MJ, Harrison TA, Hidaka A, Hoffmeister M, Huyghe JR, Joshi AD, Kawaguchi ES, Keku TO, Kundaje A, Le Marchand L, Lewinger JP, Li L, Lynch BM, Mahesworo B, Männistö S, Moreno V, Murphy N, Newcomb PA, Obón-Santacana M, Ose J, Palmer JR, Papadimitriou N, Pardamean B, Pellatt AJ, Peoples AR, Platz EA, Potter JD, Qi L, Qu C, Rennert G, Ruiz-Narvaez E, Sakoda LC, Schmit SL, Shcherbina A, Stern MC, Su Y-R, Tangen CM, Thomas DC, Tian Y, Um CY, van Duijnhoven FJ, Van Guelpen B, Visvanathan K, Wang J, White E, Wolk A, Woods MO, Ulrich CM, Hsu L, Gauderman WJ, Peters U, Tsilidis KK. (2023). Genome-wide interaction analysis of folate for colorectal cancer risk.. Am J Clin Nutr. 118. 5. (pp. 881-891).
dc.identifier.doi10.1016/j.ajcnut.2023.08.010
dc.identifier.eissn1938-3207
dc.identifier.elements-typejournal-article
dc.identifier.issn0002-9165
dc.identifier.piiS0002-9165(23)66108-8
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/69786
dc.languageeng
dc.publisherElsevier B.V.
dc.publisher.urihttps://www.sciencedirect.com/science/article/pii/S0002916523661088
dc.relation.isPartOfAm J Clin Nutr
dc.rights(c) The author/sen
dc.rights.licenseCC BYen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectCRC
dc.subjectEuropean
dc.subjectGWIS
dc.subjectSYN2
dc.subjectTIMP4
dc.subjectcolorectal cancer
dc.subjectfolate
dc.subjectfolic acid
dc.subjectgenome-wide
dc.subjectinteraction
dc.subjectsynapsin
dc.subjecttissue inhibitor of metalloproteinase 4
dc.subjectHumans
dc.subjectFolic Acid
dc.subjectRisk Factors
dc.subjectColorectal Neoplasms
dc.subjectCase-Control Studies
dc.subjectDietary Supplements
dc.titleGenome-wide interaction analysis of folate for colorectal cancer risk.
dc.typeJournal article
pubs.elements-id480302
pubs.organisational-groupCollege of Health
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