Non-Targeted Metabolomic Profiling Identifies Metabolites with Potential Antimicrobial Activity from an Anaerobic Bacterium Closely Related to Terrisporobacter Species.

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dc.citation.issue2
dc.citation.volume13
dc.contributor.authorPahalagedara ASNW
dc.contributor.authorFlint S
dc.contributor.authorPalmer J
dc.contributor.authorBrightwell G
dc.contributor.authorLuo X
dc.contributor.authorLi L
dc.contributor.authorGupta TB
dc.contributor.editorEisenreich W
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-07-24T21:32:41Z
dc.date.available2024-07-24T21:32:41Z
dc.date.issued2023-02-09
dc.description.abstractThis work focused on the metabolomic profiling of the conditioned medium (FS03CM) produced by an anaerobic bacterium closely related to Terrisporobacter spp. to identify potential antimicrobial metabolites. The metabolome of the conditioned medium was profiled by two-channel Chemical Isotope Labelling (CIL) LC-MS. The detected metabolites were identified or matched by conducting a library search using different confidence levels. Forty-eight significantly changed metabolites were identified with high confidence after the growth of isolate FS03 in cooked meat glucose starch (CMGS) medium. Some of the secondary metabolites identified with known antimicrobial activities were 4-hydroxyphenyllactate, 3-hydroxyphenylacetic acid, acetic acid, isobutyric acid, valeric acid, and tryptamine. Our findings revealed the presence of different secondary metabolites with previously reported antimicrobial activities and suggested the capability of producing antimicrobial metabolites by the anaerobic bacterium FS03.
dc.description.confidentialfalse
dc.edition.editionFebruary 2023
dc.format.pagination252-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/36837871
dc.identifier.citationPahalagedara ASNW, Flint S, Palmer J, Brightwell G, Luo X, Li L, Gupta TB. (2023). Non-Targeted Metabolomic Profiling Identifies Metabolites with Potential Antimicrobial Activity from an Anaerobic Bacterium Closely Related to Terrisporobacter Species.. Metabolites. 13. 2. (pp. 252-).
dc.identifier.doi10.3390/metabo13020252
dc.identifier.eissn2218-1989
dc.identifier.elements-typejournal-article
dc.identifier.issn2218-1989
dc.identifier.number252
dc.identifier.piimetabo13020252
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70326
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2218-1989/13/2/252
dc.relation.isPartOfMetabolites
dc.subjectanaerobic bacteria
dc.subjectantimicrobial metabolites
dc.subjectnon-targeted metabolomics
dc.titleNon-Targeted Metabolomic Profiling Identifies Metabolites with Potential Antimicrobial Activity from an Anaerobic Bacterium Closely Related to Terrisporobacter Species.
dc.typeJournal article
pubs.elements-id460117
pubs.organisational-groupCollege of Health
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