The Effects of GreenShell Mussel Powder (Brand-Named PERNAULTRA) on Physical Performance and Subjective Pain, Symptoms, and Function Measures in Knee Osteoarthritis: A 6-Mo Randomized, Double-Blind, Placebo-Controlled Trial

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dc.citation.issue4
dc.citation.volume8
dc.contributor.authorSlade CAJ
dc.contributor.authorKruger MC
dc.contributor.authorMiller MR
dc.contributor.authorMazahery H
dc.contributor.authorBeck KL
dc.contributor.authorConlon CA
dc.contributor.authorVon Hurst PR
dc.date.accessioned2024-04-25T23:37:46Z
dc.date.accessioned2024-07-25T06:37:16Z
dc.date.available2024-03-27
dc.date.available2024-04-25T23:37:46Z
dc.date.available2024-07-25T06:37:16Z
dc.date.issued2024-04
dc.description.abstractBackground: Osteoarthritis (OA) can cause disability and reduce quality of life (QoL). Objectives: This study aimed to determine whether GreenShell mussel (GSM) powder (PERNAULTRA) consumption was more effective than placebo at improving physical performance and subjective measures of symptoms and function in adults with early signs of knee OA. Methods: The Researching Osteoarthritis and GSM study was a 6-mo randomized, double-blind, placebo-controlled trial in adults aged 55–80 y, screened for signs of OA (n = 120, 65.9 ± 6.43 y, 63% female). Participants consumed either 3 g of powdered whole GSM or placebo (pea protein) daily. Baseline and end data collection included 30-s chair stand, stair test, 40-m fast-paced walk test, Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaire categorized into 5 subscales [pain (P), symptoms except pain (S), function in activities of daily living (ADL), function in sports/recreation (SP), and QoL], a measure of Intermittent and Constant Osteoarthritis Pain, and visual analog scale of pain and symptoms. Results: Visual analog scale symptoms showed a significantly greater reduction in percentage change for GSM than that for placebo [−28.1 (−59.2, 43.2) compared with 0.00 (−28.6, 100); P = 0.03]. Further, a trend for improvement in percentage change for GSM compared with placebo was seen in 40m fast-paced walk [2.51 (−3.55, 8.12) compared with 0.20 (−6.58, 4.92); P = 0.09], KOOS-SP [11.4 (−4.48, 27.0) compared with 0.00 (−11.1, 17.7); P = 0.09], and Intermittent and Constant Osteoarthritis Pain intermittent pain scale [−27.7 (−77.3, 0.00) compared with −14.6 (−50.0, 36.4); P = 0.08]. In those with body mass index (BMI; in kg/m2) <25, GSM consumption significantly improved KOOS-S compared with placebo [6.35 (3.49, 12.7) compared with 0.00 (−4.65, 4.49); P = 0.03] and showed a trend for improvement in KOOS-ADL [3.29 (1.01, 8.79) compared with 1.01 (−5.75, 4.30); P = 0.07]. Those with BMI of ≥25, consuming GSM showed a trend for improvement in KOOS-SP [13.6 (−4.76, 33.3) compared with 0.00 (−12.5, 20.0); P = 0.07]. Conclusions: This research suggests consumption of GSM has potential to alleviate symptoms and improve functionality in OA. This trial was registered at Clinical Trial Registry as ACTRN12620001112954p (https://www.anzctr.org.au/ACTRN12620001112954p.aspx).
dc.description.confidentialfalse
dc.edition.editionApril 2024
dc.identifier.citationSlade CA, Kruger MC, Miller MR, Mazahery H, Beck KL, Conlon CA, von Hurst PR. (2024). The Effects of GreenShell Mussel Powder (Brand-Named PERNAULTRA) on Physical Performance and Subjective Pain, Symptoms, and Function Measures in Knee Osteoarthritis: A 6-Mo Randomized, Double-Blind, Placebo-Controlled Trial. Current Developments in Nutrition. 8. 4.
dc.identifier.doi10.1016/j.cdnut.2024.102148
dc.identifier.eissn2475-2991
dc.identifier.elements-typejournal-article
dc.identifier.issn2475-2991
dc.identifier.number102148
dc.identifier.piiS2475299124000829
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70555
dc.languageEnglish
dc.publisherElsevier Inc. on behalf of American Society for Nutrition
dc.publisher.urihttps://www.sciencedirect.com/science/article/pii/S2475299124000829
dc.relation.isPartOfCurrent Developments in Nutrition
dc.rights(c) 2024 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectGreenShell mussels
dc.subjectosteoarthritis
dc.subjectKOOS
dc.subjectICOAP
dc.subjectperformance
dc.subjectolder adults
dc.titleThe Effects of GreenShell Mussel Powder (Brand-Named PERNAULTRA) on Physical Performance and Subjective Pain, Symptoms, and Function Measures in Knee Osteoarthritis: A 6-Mo Randomized, Double-Blind, Placebo-Controlled Trial
dc.typeJournal article
pubs.elements-id488368
pubs.organisational-groupCollege of Health
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