Loss of fertility in the absence of progesterone receptor expression in kisspeptin neurons of female mice

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dc.citation.issue7
dc.citation.volume11
dc.contributor.authorGal A
dc.contributor.authorLin PC
dc.contributor.authorCacioppo JA
dc.contributor.authorHannon PR
dc.contributor.authorMahoney MM
dc.contributor.authorWolfe A
dc.contributor.authorFernandez-Valdivia R
dc.contributor.authorLydon JP
dc.contributor.authorElias CF
dc.contributor.authorKo CM
dc.date.available2016-07-21
dc.date.available2016-07-05
dc.date.issued1/07/2016
dc.description.abstract© 2016 Gal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Ovarian steroids, estradiol and progesterone, play central roles in regulating female reproduction by acting as both positive and negative regulators of gonadotropin-releasing hormone (GnRH) secretion in the hypothalamus. Recent studies have identified kisspeptin neurons of the hypothalamus as the target of estrogenic regulation of GnRH secretion. In this study, we aimed to determine the significance of progesterone receptor (PGR) expression in the kisspeptin neurons. To this end, the Pgr gene was selectively ablated in mouse kisspeptin neurons and the reproductive consequence assessed. The hypothalamus of the Pgr deficient female mouse expressed kisspeptin, the pituitary released LH in response to GnRH stimulation, and the ovary ovulated when stimulated with gonadotropins. However, the mutant mouse gradually lost cyclicity, was unable to generate a LH surge in response to rising estradiol, and eventually became infertile. Taken together, these results indicate that the loss of PGR impairs kisspeptin secretory machinery and therefore that PGR plays a critical role in regulating kisspeptin secretion.
dc.description.publication-statusPublished
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000380797500089&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifierARTN e0159534
dc.identifier.citationPLOS ONE, 2016, 11 (7)
dc.identifier.doi10.1371/journal.pone.0159534
dc.identifier.elements-id271477
dc.identifier.harvestedMassey_Dark
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10179/9802
dc.relation.isPartOfPLOS ONE
dc.titleLoss of fertility in the absence of progesterone receptor expression in kisspeptin neurons of female mice
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Sciences
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